XB-FEAT-6033289

loc100133315

This is the community wiki page for the gene loc100133315 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

synteny Xenopus vs Human

the identify of this gene needs further investigation

In X tropicalis v10 genome, the order on Chr2 is: lrif1> <trpc2 <loc100133315 numa1> <il18bp tmem216> <lamtor

trpc2 and loc100133315 models may be non overlapping sequences but of the same allele ( ie together they make full trpc2 sequence)

BLAST alignment of the 2 sequences show no significant similarity so loc100133315 does not represent a duplication of trpc2.

nomenclature changes

this gene/symbol was renamed from XB6033289 provisional ortholog of transient receptor potential cation channel, subfamily C, member 2-like (loc100133315) to Xrcc1 N-terminal domain containing 1 (xndc1) following mouse nomenclature and recommendations from a review by the NCBIs RefSeq project and HUGO Gene Nomenclature Committee

JIRA reference: HGNC-100

URL: [1]

They wrote "In vertebrates we've overlooked annotating the XNDC1 gene upstream of TRPC2 due to over-extension of the TRPC2 CDS (PMID: 21854574). The over-extension of the TRPC2 CDS arose in part because these two genes are pseudogenized in human while readthrough transcription occurs in mouse. Below are suggested updates needed for the proper annotation of the XNDC1 gene."