BMS-453

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Description

Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

Bms 453 structure, image from NCBI Pubchem

Alternative Name

BMS 189453

Chemical Name

4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid

Suppliers

Tocris

References