XB-FEAT-6043867: Difference between revisions
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='' | =''hepacam2''= | ||
This is the community wiki page for the gene '' | This is the community wiki page for the gene ''hepacam2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=summary from NCBI for human HEPACAM2= | |||
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016]. | |||
=synteny and orthology= | |||
The ''Xenopus'' ''hepacam2'' gene is considered the true ortholog of Human HEPACAM2, based on conserved synteny and protein architecture. | |||
Synteny pattern: | |||
Xenopus hepacam2 is on chr6/6L/6S: samd9l .. '''hepacam2''' ... vps50... Loc# ..LOC# ... calcr | |||
human: SAMD9L ... '''HEPACAM2''' ...VPS50 ....// | |||
NB: A second 'hepacam2' like gene is found in ''Xenopus'' on chromosomes 1/1L/1S, represented on XB-GENEPAGE-22166507, and it is therefore '''NOT''' the true ortholog of the human HEPACAM2. | |||
''Xenopus'' ''hepacam2l'' on Chr1/1L/1S: adissp> ... hspa12b< ... lyrm2< ... '''hepacam2l'''< ... gpr151 ... rnf145l | |||
Latest revision as of 09:09, 25 April 2023
hepacam2
This is the community wiki page for the gene hepacam2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
summary from NCBI for human HEPACAM2
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis. Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients. [provided by RefSeq, Oct 2016].
synteny and orthology
The Xenopus hepacam2 gene is considered the true ortholog of Human HEPACAM2, based on conserved synteny and protein architecture.
Synteny pattern:
Xenopus hepacam2 is on chr6/6L/6S: samd9l .. hepacam2 ... vps50... Loc# ..LOC# ... calcr
human: SAMD9L ... HEPACAM2 ...VPS50 ....//
NB: A second 'hepacam2' like gene is found in Xenopus on chromosomes 1/1L/1S, represented on XB-GENEPAGE-22166507, and it is therefore NOT the true ortholog of the human HEPACAM2.
Xenopus hepacam2l on Chr1/1L/1S: adissp> ... hspa12b< ... lyrm2< ... hepacam2l< ... gpr151 ... rnf145l