PP2 and Hydroxyurea: Difference between pages
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==Description== | ==Description== | ||
Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C560] | |||
[[File:Hydroxyureal.structure.png|frame|right|Hydroxyurea structure, image from NCBI Pubchem]] | |||
==Alternative Names== | |||
* Hydroxycarbamide | |||
* N-Hydroxyurea | |||
[[File: | * Hydrea | ||
* Onco-carbide | |||
== | ==Chemical Name== | ||
* | Hydroxyurea | ||
==Suppliers== | ==Suppliers== | ||
[http://www.sigmaaldrich.com/catalog/product/sigma/h8627? Sigma] | |||
==References== | ==References== | ||
*[http://www.xenbase.org/literature/article.do?articleId=44961&method=display| ''Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.'' Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.] | |||
*National Center for Biotechnology Information. PubChem Compound Database; CID=3657, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3657] | |||
*[http://www.xenbase.org/literature/article.do?method=display | |||
*[http:// | |||
Latest revision as of 07:42, 9 August 2016
Description
Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[1]
Alternative Names
- Hydroxycarbamide
- N-Hydroxyurea
- Hydrea
- Onco-carbide
Chemical Name
Hydroxyurea
Suppliers
References
- Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes. Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.
- National Center for Biotechnology Information. PubChem Compound Database; CID=3657, [2]