PP2 and Hydroxyurea: Difference between pages

Latest revision as of 07:42, 9 August 2016

Description

Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[1]

Hydroxyurea structure, image from NCBI Pubchem

Alternative Names

Hydroxycarbamide
N-Hydroxyurea
Hydrea
Onco-carbide

Chemical Name

Hydroxyurea

Suppliers

Sigma

References

Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes. Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.
National Center for Biotechnology Information. PubChem Compound Database; CID=3657, [2]

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 ==Description==
-Synonym: 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879
+Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C560]
+[[File:Hydroxyureal.structure.png|frame|right|Hydroxyurea structure, image from NCBI Pubchem]]
-"PP2 is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2."
+==Alternative Names==
-*-Sigma Product Description
+* Hydroxycarbamide
+* N-Hydroxyurea
-[[File:PP2.png|frame|right|PP2 structure, photo from Sigma-Aldrich]]
+* Hydrea
+* Onco-carbide
-==Genes Affected==
+==Chemical Name==
-*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=489819 src]
+Hydroxyurea
 ==Suppliers==
-*[http://www.emdmillipore.com/US/en/product/PP2---CAS-172889-27-9---Calbiochem,EMD_BIO-529573?bd=1 Calbiochem is now EMD Millipore]
+[http://www.sigmaaldrich.com/catalog/product/sigma/h8627? Sigma]
-*[http://www.sigmaaldrich.com/catalog/product/sigma/p0042?lang=en&region=US Sigma]
-==Usage Notes==
-uM in cell culture media, up to 10mM in certain applications
 ==References==
-*[https://pubchem.ncbi.nlm.nih.gov/compound/4878]
+*[http://www.xenbase.org/literature/article.do?articleId=44961&method=display| ''Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.'' Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.]
-*[https://pubchem.ncbi.nlm.nih.gov/compound/4878 PubChem]
+*National Center for Biotechnology Information. PubChem Compound Database; CID=3657, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3657]
-*[http://www.xenbase.org/literature/article.do?method=display&articleId=1490 Robles et al., 2005]
-*[http://www.xenbase.org/literature/article.do?method=display&articleId=9003 Browaeys-Poly et al. 2001]
->18 Xenbase articles contain a reference to PP2 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
-*
-*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]