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| ==Description==
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| Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C560]
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| [[File:Hydroxyureal.structure.png|frame|right|Hydroxyurea structure, image from NCBI Pubchem]]
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| ==Alternative Names==
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| * Hydroxycarbamide
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| * N-Hydroxyurea
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| * Hydrea
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| * Onco-carbide
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| ==Chemical Name==
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| Hydroxyurea
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| ==Suppliers==
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| [http://www.sigmaaldrich.com/catalog/product/sigma/h8627? Sigma]
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| ==References==
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| *[http://www.xenbase.org/literature/article.do?articleId=44961&method=display| ''Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.'' Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.]
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| *National Center for Biotechnology Information. PubChem Compound Database; CID=3657, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3657]
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Revision as of 11:05, 18 August 2016
