XB-FEAT-6044533: Difference between revisions
imported>Xenbase (→nat8.9) |
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=nat8.9= | =nat8.9= | ||
This is the community wiki page for the gene ''nat8.9'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | This is the community wiki page for the gene ''nat8.9'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=nomenclature changes= | |||
NOV 2019 | |||
This gene represents one of 9 duplicated ''nat8'' genes identified by Xenbase during analysis ''Xenopus'' v9/10 genome annotation, all on Chromosome 1 in ''X. tropicalis'' and ''X. laevis'', and is true ortholog of the human NAT8B gene. | |||
Note that not all duplications are present in ''X. tropicalis'', and ''X. laevis'' does not always have both .L and .S homeologs. | |||
=NCBI Summary for human NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)= | =NCBI Summary for human NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)= | ||
The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008] | The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008] | ||
Revision as of 08:45, 30 June 2020
nat8.9
This is the community wiki page for the gene nat8.9 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
NOV 2019 This gene represents one of 9 duplicated nat8 genes identified by Xenbase during analysis Xenopus v9/10 genome annotation, all on Chromosome 1 in X. tropicalis and X. laevis, and is true ortholog of the human NAT8B gene.
Note that not all duplications are present in X. tropicalis, and X. laevis does not always have both .L and .S homeologs.
NCBI Summary for human NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)
The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]