XB-FEAT-876755: Difference between revisions
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=nfatc1= | =nfatc1= | ||
This is the community wiki page for the gene ''nfatc1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''nfatc1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
04/22/ 2016 | |||
Human name has changed for Entrez Gene: 4772. From nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 to nuclear factor of activated T-cells 1 | |||
12/18/2017 | |||
Human name has changed for Entrez Gene: 4772. From nuclear factor of activated T-cells 1 to nuclear factor of activated T cells 1 | |||
=NCBI Summary= | |||
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] | |||
Latest revision as of 08:54, 3 January 2018
nfatc1
This is the community wiki page for the gene nfatc1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
04/22/ 2016
Human name has changed for Entrez Gene: 4772. From nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 to nuclear factor of activated T-cells 1
12/18/2017 Human name has changed for Entrez Gene: 4772. From nuclear factor of activated T-cells 1 to nuclear factor of activated T cells 1
NCBI Summary
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]