XB-FEAT-5734493

rasef-like

This is the community wiki page for the gene rasef please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

09/14/2021

The name of this gene (XB-GENEPAGE-5734493, NCBI GeneID:100379934, XP_002932289.1) was changed from rasef , ras and EF-hand domain-containing protein to rasef-like , ras and EF-hand domain-containing protein-like, as represents a rasef-like gene that was lost in the ancestor of mammals. The orthologs have been removed from this Xenbase gene page ( and placed on the true rasef gene page).

rasef-like is very similar protein-wise to the true rasef, according to alignment in COBALT, and is flanked by different genes of course

in Gallus gallus (chicken) , the gene was already called 'ras and EF-hand domain-containing protein-like'.

Note that based on synteny (the conserved gene block), XB-GENE-1002558, NCBI GeneID: 780339, NP_001072877.1 represents the true ortholog to human RASEF (GeneID:158158), and accordingly it's name was changed from mgc147600 to rasef.

Synteny pattern

For this rasef-like gene, the synteny data in Latimeria chalumnae and non-mammalian tetrapods is generally:

PDIA3>...ELL3<...FKBP8-like>...SERF2>...RASEF-like<...ADAMTSL5-like>...SERINC4<...HYPK>.

In chondrichthyes and teleosts this synteny is somewhat conserved but the gene block is often shorter or re-arranged. The neighboring FKBP8-like and ADAMTSL5-like genes are also often lost (or possibly unannotated) in reptiles and mammals.

According to the v10 genome annotations, for X. tropicalis and X. laevis, Xenopus 'rasef-like' is on Chr3. Note that X. laevis has lost "serinc4. L and .S".

Xtrop: serf2 ... rasef-like ... adamtsl5 ... serinc4 ... hypk

Xlaevis.L: serf2.L ... rasef-like.L ... adamtsl5.L ... hypk.L

Xlaevis.S LOC# ... rasef-like.S... adamtsl5.S ... hypk.S (reversed order)

Human: SERF2 .. SERF2-C15orf63 ... SERINC4 ...HYPK

Gallus: : SERF2 ... LOC100858360 ... SERINC4 ...HYPK