Concanamycin

Description

V-ATPase inhibitor, see fusicoccin for an activator.

"Cytotoxic. Inhibits acidification of organelles and perforin-mediated cytotoxicity."

• • -Sigma Description

"Specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines."

• • -Tocris Description

Concanamycin A structure, photo from Sigma-Aldrich

Suppliers

• Sigma-Aldrich c9705
• Tocris 2656
• Santa Cruz sc-202111

Usage Notes

2M

References

• Cheng et al., 2002

>11 Xenbase articles contain a reference to concanamycin according to textpresso including these:

• Adams 2006
• Coombs 2010
• Adams 2007
• Hrycyna 2014
• Buttner 2001
• Slack 2007
• Adams 2013
• Londino 2013
• Taunton 2000
• Tseng 2008
• Jansen 2010
• Tseng 2010