XB-FEAT-986529: Difference between revisions
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This is the community wiki page for the gene ''antxr1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''antxr1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=Nomenclature changes= | |||
05.22.2018 | |||
Human name has changed for Entrez Gene: 84168. From anthrax toxin receptor 1 to ANTXR cell adhesion molecule 1 | |||
=summary from NCBI = | |||
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] | |||
Latest revision as of 05:56, 24 May 2018
antxr1
This is the community wiki page for the gene antxr1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
Nomenclature changes
05.22.2018
Human name has changed for Entrez Gene: 84168. From anthrax toxin receptor 1 to ANTXR cell adhesion molecule 1
summary from NCBI
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]