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| ==Description==
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| Phosphodiesterase inhibitor.
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| "Biochem/physiol Actions: Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."
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| *-Sigma Product Description
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| [[File:IBMX.png|frame|right|IBMX structure, photo from Sigma-Aldrich]]
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| ==Genes Affected==
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| ==Suppliers==
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| *[http://www.tocris.com/dispprod.php?ItemId=5345#.VWx399JVhBc Tocris 2845]
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| *[https://www.caymanchem.com/app/template/Product.vm/catalog/13347 Cayman 13347]
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| *[http://www.scbt.com/datasheet-201188-ibmx.html Santa Cruz sc-201188]
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| *[http://www.enzolifesciences.com/BML-PD140/ibmx/ Enzo]
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| *[https://www.lifetechnologies.com/order/catalog/product/PHZ1124 Life Technologies PHZ1124]
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| *[http://www.abcam.com/ibmx-ab120840.html Abcam ab120840]
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| *[http://www.sigmaaldrich.com/catalog/product/sigma/i5879?lang=en®ion=US Sigma-Aldrich i5879]
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| ==Usage Notes==
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| 1mM
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| ==References==
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| *[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999]
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| >452 Xenbase articles contain a reference to IMBX according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
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| *
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| *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]
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Revision as of 12:53, 8 August 2016
