Fbxl21 and Chymostatin: Difference between pages

Revision as of 07:53, 1 June 2015

Description

"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."

- -Santa Cruz product description

Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)

Chymostatin structure, photo from Sigma-Aldrich

Suppliers

Usage Notes

References

Tian et al., 1997

>464 Xenbase articles contain a reference to chymostatin according to textpresso

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-#REDIRECT [[XB-FEAT-987710]]
+==Description==
+"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."
+**-Santa Cruz product description
+Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)
+[[File:chymostatin.png|frame|right|Chymostatin structure, photo from Sigma-Aldrich]]
+==Suppliers==
+*[https://www.caymanchem.com/app/template/Product.vm/catalog/15114 Cayman]
+*[http://www.scbt.com/datasheet-202541-chymostatin.html Santa Cruz]
+*[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore]
+*[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en&region=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma]
+**Genes Affected
+**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5953470 stsg]
+==Usage Notes==
+==References==
+*[http://www.xenbase.org/literature/article.do?method=display&articleId=16255 Tian et al., 1997]
+>464 Xenbase articles contain a reference to chymostatin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
+*
+*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]