XB-FEAT-990957: Difference between revisions
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=dlec1= | =dlec1= | ||
This is the community wiki page for the gene ''dlec1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''dlec1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=summary from NCBI= | |||
In humans, the cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016] | |||
=nomenclature issues= | |||
05.14.2018 | |||
Human name has changed for Entrez Gene: 9940. From deleted in lung and esophageal cancer 1 to DLEC1, cilia and flagella associated protein | |||
Latest revision as of 11:36, 15 May 2018
dlec1
This is the community wiki page for the gene dlec1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
summary from NCBI
In humans, the cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]
nomenclature issues
05.14.2018 Human name has changed for Entrez Gene: 9940. From deleted in lung and esophageal cancer 1 to DLEC1, cilia and flagella associated protein