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| =chrna7= | | == Latest-fashion Veer The prepossession,Rumbling as a function to to own it! == |
| This is the community wiki page for the gene ''chrna7'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
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| =summary from NCBI= | | This two volume Taschen special edition set, <a href=http://www.cljy.net>discount Gucci handbags</a> which compiles highlights from Tasche's <a href=http://www.illyris.com>Balenciaga Handbags</a> Fashion Now series, <a href=http://www.hipngeek.com>Hermes bags</a> provides a comprehensive overview of fashion design around <a href=http://www.51srdy.com>Louis vuitton replica handbags</a> the world at the start of the twenty-first century. |
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| The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. T
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| he nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.
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| The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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| This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia.
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| An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.
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| Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
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Revision as of 14:18, 22 October 2010
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