Difference between revisions of "XB-FEAT-993074"

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=selenow=  
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=selenow1=  
This is the community wiki page for the gene ''selenow'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
+
This is the community wiki page for the gene ''selenow1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
  
 
=nomenclature changes=
 
=nomenclature changes=
 
11/07/2016
 
11/07/2016
 +
 
Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW
 
Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW
  
Line 13: Line 14:
  
 
09/12/2017
 
09/12/2017
correspondance from Bhanu Rajput, Ph. D.
 
Staff Scientist
 
Reference Sequence Project
 
NCBI/NLM/NIH
 
2.  ... issue concerning selenow gene.
 
  
XB-GENE-993075 was previously associated with GeneID:100145402, which was withdrawn because it
+
correspondance from Bhanu Rajput, Ph. D. [Staff Scientist Reference Sequence Project NCBI/NLM/NIH]
was based on a zebrafish transcript (BC160969.1) that was erroneouslyannotated as Xenopus tropicalis.  
+
2.) issue concerning selenow gene.  
  
He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now  represents Xt selenow gene.  
+
XB-GENE-993075 was previously associated with Entrez GeneID:100145402, which was withdrawn because it
 +
was based on a zebrafish transcript (BC160969.1) that was erroneously annotated as ''Xenopus tropicalis''.
 +
 
 +
He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene.  
  
 
While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358).  
 
While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358).  
This locus needs official nomenclature.
 
  
To comply with Gladyshev et al.'s recommendation for naming paralogs withsuffixes on the symbols (PMID:27645994, Table 3), he suggested the
+
This locus needs official nomenclature, and will be known by symbol ''selenow2''     with gene name ''selenoprotein W2'' (see below).
 +
 
 +
To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), he suggested the
 
following nomenclature for the 2 paralogs:
 
following nomenclature for the 2 paralogs:
 
 
  
current                                       symbol          name
+
[[current]]                                       [[changes to > new symbol          new name]]
  
selenow (XB-GENE-993075) >  selenow1     selenoprotein W1
+
selenow (XB-GENE-993075) changes to >  selenow1     selenoprotein W1
  
 
+
new gene GeneID:101731107 chnages to  > selenow2     selenoprotein W2
new gene GeneID:101731107  >      selenow2     selenoprotein W2
 
  
 
ACTION BY XENBASE: 09/12/17
 
ACTION BY XENBASE: 09/12/17
CHANGED SELENOW TO SELENOW1 AS REQUESTED
+
 
SUBMIT SELENOW2 DATA FOR REQUEST NEW GENE PAGE
+
CHANGED name from SELENOW to SELENOW1 , as requested
 +
Submitted SELENOW2 data and requested a new gene page.
 +
 
 +
NEW GENE PAGE created : XB-GENEPAGE:22041594
  
 
=NCBI summary=
 
=NCBI summary=
 
Summary
 
Summary
 
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]
 
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]

Latest revision as of 16:15, 30 June 2020

selenow1

This is the community wiki page for the gene selenow1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

11/07/2016

Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW

Human symbol has changed for Entrez Gene: 6415. From SEPW1 to SELENOW

Human name has changed for Entrez Gene: 6415. From selenoprotein W, 1 to selenoprotein W

Mouse symbol has changed for Entrez Gene: 20364. From Sepw1 to Selenow

09/12/2017

correspondance from Bhanu Rajput, Ph. D. [Staff Scientist Reference Sequence Project NCBI/NLM/NIH] 2.) issue concerning selenow gene.

XB-GENE-993075 was previously associated with Entrez GeneID:100145402, which was withdrawn because it was based on a zebrafish transcript (BC160969.1) that was erroneously annotated as Xenopus tropicalis.

He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene.

While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358).

This locus needs official nomenclature, and will be known by symbol selenow2     with gene name selenoprotein W2 (see below).

To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), he suggested the following nomenclature for the 2 paralogs:

current                     [[changes to > new symbol       new name]]

selenow (XB-GENE-993075) changes to >  selenow1     selenoprotein W1

new gene GeneID:101731107 chnages to > selenow2     selenoprotein W2

ACTION BY XENBASE: 09/12/17

CHANGED name from SELENOW to SELENOW1 , as requested Submitted SELENOW2 data and requested a new gene page.

NEW GENE PAGE created : XB-GENEPAGE:22041594

NCBI summary

Summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]