View source for Y27632

==Description==
"Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP."
*-Sigma Product Description
[[File:Y27632.png|frame|right|Y27632 structure, photo from Sigma-Aldrich]]

==Genes Affected==
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=984660 rock1]
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=959450 rock2]
==Suppliers==
*[http://www.sigmaaldrich.com/catalog/product/sigma/y0503?lang=en&region=US Sigma]
*[http://www.tocris.com/dispprod.php?ItemId=1382#.VZWg2RtVhBc Tocris]

==Usage Notes==
10uM in culture
==References==
*[https://pubchem.ncbi.nlm.nih.gov/compound/448042 Pubchem]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=44762 Langdon et al., 2012]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=41781 Zhou]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=49645 Kim]

>28 Xenbase articles contain a reference to Y27632 or Y-27632 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
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