XB-FEAT-486273

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c3

This is the community wiki page for the gene c3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

in situ preparation note

Some of the community submitted images from the Patient lab for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB).

nomenclature changes

02.25.20 name changed from 'complement component 3' to 'complement C3' following human nomenclature.

Summary for human C3 from NCBI

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]