XB-FEAT-1013383

neil1

This is the community wiki page for the gene neil1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene expression notes

neil1 is only expressed in very low levels of the embryo, and therefore there are no ISH images published or yet avavilable. Christoph Niehrs works on the this gene, and has used MOs to knockout/down, with significant phenotypic effects.

NCBI summary

This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]