XB-FEAT-479311

slc12al3

This is the community wiki page for the gene slc12a3l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

gene nomenclature updates

11.28.18

KAB changed symbol from slc12a3.2 to slc12a3l because this is not a duplication within a locus

17JULY2022

Human-Like symbol has changed for genepage ID: 479311 From slc12a3l to SLC12A3

Note that X.laevis slc12a3.L gene model was out of date on the gene page- requested update from v6 model to v10 gene model XBXL10_1g2442. (Confirmed by synteny)

synteny pattern in Xenopus

Xenopus slc12a3-like genes, and orthologs of each other, but are not seen in human.

Xtrop Chr1: plp4p1 ... osgep ...apex1 ... slc12a3 ...[ ~20 olfactory receptors] ... slc39a2

Xla Chr1.L: .............. osgep.L ... apex1.L ... LOC108695638 ... [ ~18x olfactory receptors] ...slc39a2.L

Xla Chr1.S: plp4p1.S ... LOC121399467 ... apex1.S ... slc12a3.S ... [~7 olfactory receptors] ...

HUMAN CHR14: OSGEP< LOC#2315(OSEGEP/APEX1 PROMOTER) > APEX1> LOC#8010(SHARPR)> PIP4P1< LOC(ENHANCER)> LOC(ENHANCER)> PNP>

true slc12a3 genes are on Chr 4 in Xenopus and have conserved flanking gene like Human:

Human Chr16: NUP93> SLC12A3> [ stack of histone tags enhancer elements] HERPUD1>

Xtr.Chr4: nlrc5< cetp< herpud1< slc12a3< LOC10049537(mt-like)< LOC116410391(mt-like) < mt4< nudt21< ogfod1< amfr<