XB-FEAT-29071357
il12b2
nomenclature changes
05MAy2023
Following recommendation from NCBI RefSeq (RSCOM-449) and Zfin, this gene changed its gene symbol and gene name from il12bl, interleukin 12B-like to il12b2, interleukin 12B 2
comment: The synteny pattern and gene loss for IL12B-like is fairly clear in tetrapods but harder to follow in teleosts. The spotted gar GeneID:102699198, XP_015215443.1 suggests the orthologous Zebrafish gene is si:dkey-88e18.2. The new gene name and symbol can also be applied to chicken GeneID:101747944 (CGNC:67435) XP_025006217.3 and Xenopus GeneID:100493914 XP_031750962.1
=synteny of IL12B genes across vertebrates :
Source: David Webb, NCBi RefSeq team.
Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1
EBF1< RNF145< UBLCP1> IL12B< LOCs>>> ADRA1B> TTC1> PWWP2A<
Gg NP_998736.1, emu XP_025974440.1, crocodile XP_019390924,
FBXO38< spink-like< IL12B< LOCs> ADRA1B> TTC1> PWWP2A<
C.midas XP_007057329.3
FBXO38< spink-like< spink-like< IL12B< ADRA1B> TTC1> PWWP2A<
P. muralis XP_028576963.1
FBXO38< spink-like< spink-like> IL12B< KCNIP1< KCNMB1>
Xenopus tropicalis XP_031754537.1
EBF4< RNF145< UBLCP1> mmp21-like< IL12B< ADRA1B> havcr1-like< havcr1-like<
Protopterus XP_043925850.1
ebf1< RNF145< UBLCP1> mmp21-like< IL12B< [unannotated region]
Gar XP_006631788.2, sterlet XP_033907726.1
EBF1< RNF145< UBLCP1> mmp21-like< IL12B< EFCAB9> UBTD2<
skate XP_032885430.1 (note downstream synteny to IL12B-like)
ADAM19> UBLCP1> mmp21-like< IL12B< DOCK2> INSYN2B
D.rerio GeneID: 445373 (il12ba) ZDB-GENE-050525-3 & GeneID:335994 (il12bb) ZDB-GENE-030131-7937?
EBF1a< RNF145a< IL12Ba< ADRB2A> SH3TC2<
RARS< UBLCP1> IL12Bb< UBTD2< ADRB2b>
Here's the synteny of IL12B-like ( now called il12b2) that is lost in mammals:
Gallus GeneID:101747944 XP_025006217.3
LBX2< PCGF1< TLX2> nefll> il12b-like< DQX1< dock2> insyn2b< bnip3L< AUP1< HTRA2>
Chelonia mydas
LBX2< PCGF1< TLX2> nefll> il12b-like< DQX1< dock2> insyn2b<
Podarcis muralis
LBX2< PCGF1< TLX2> nefll> il12b-like< DQX1< insyn2b< bnip3L< AUP1< HTRA2>
Xenopus tropicalis GeneID: 100493914 XP_031750962.1
TLX2> mmp21< il12b-like< DQX1< AUP1< HTRA2>
Gar XP_015215443.1
TLX2> npm-like> fgf18L> PCGF1>// il12b-like< dqx1< avp<
Skate XP_032900156.1 //il12b-like< DQX1< DOCK2L> insyn2b< bnip3L< AUP1<
mammals
LBX2< PCGF1< TLX2> DQX1< AUP1< HTRA2>