From XenWiki
Jump to navigation Jump to search


This is the community wiki page for the gene prdm12 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

notes on current research on prdm12

prdm12 is an uncharaterised member of the zinc-finger family, being studied inXenopus in the lab of Eric Bellefroid, ULB, Belguim.

prdm12 is expressed in restricted regions of the developing nervous sytstem of Xenopus: in progeneitors of ventral spinal cord of the CNS, in the trunk region, and in the peripheral nervous system as well. prdm12 is expressed in p1 (neural ) progentors in the ventral neural tube, and acts as a repressor to dbx1 and en1 in developing spinal cord. prdm12 also appears to act as a G9a dependent repressor to induce en1 ( engrailed 1), It also binds to dbx1 promoters ( and represses dbx1 activity) and binds to nkx6.1 promtoers. prdm12 required for trigemial ganglia formation ( one fo the cranial nerves), and is expressed in dorsal root ganglia along the spinal cord in both Xenopus and mouse later stage embryos. ( E14-15)

In Human, mutations in prdm12 causes a congenital insensity to pain (CIP) ( see Chen et al. Nature Genetics 2015).