XB-FEAT-979408

fgl1a

This is the community wiki page for the gene fgl1a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

02JULY2020 Following review by David Webb at NCBI redf seq project, this gene was renamed fgl1a, fibrinogen like 1A, following the discovery of a second FGL1-like gene in non-mammalian gnathostomes , which was called fgl1b (fibrinogen like 1B).

These Xenopus genes are the true orthologs to human FGL1 and are conserved throughout gnathostomes at: ASAH1> PCM1< fgl1a> MTUS1> PDGFRL< SLC7A2<

summary for human FGL1

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]