XB-FEAT-1219056

zfyve28a

This is the community wiki page for the gene zfyve28a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenlcature updates

04/22/ 2016

Human name has changed for Entrez Gene: 57732. From zinc finger, FYVE domain containing 28 to zinc finger FYVE-type containing 28

09JAN2022

Following request from NCI\BI RefSeq team Curator David Webb:

X. tropicalis GeneID: 779953 (on Chromosome 1) gene symbol and gene name has changed from zfyve28 , zinc finger FYVE-type containing 28 to zfyve28a, zinc finger FYVE-type containing 28a

The X. laevis GeneID: 447053 (on Chromosome 3L) will be removed from XB-GENEPAGE-1219056 and added to the new Gene Page and named zfyve28b, zinc finger FYVE-type containing 28b.

Note that NCBI refSeq consider the X. laevis assembly to be too fragmented to confidently determine the other zfyve28-like genes.

Note that the human ZFYVE28 gene is named "zinc finger FYVE-type containing 28" but the protein is named "lateral signaling target protein 2 homolog". [Note how it resides next to fam193b.L]

synteny and conservation

Like most non-placental gnathostomes, Xenopus has two ZFYVE28-like genes but only one of them was informatively named.

Placental mammals likely lost one of the ZFYVE28-like genes when a gene block was translocated.

Note that the human ZFYVE28 gene is named "zinc finger FYVE-type containing 28" but the protein is named "lateral signaling target protein 2 homolog". [Note how it resides next to fam193b.L]

Two ZFYVE28 orthologous genes are present at least as far back as gnathostomes and up to marsupials while one gene copy is then lost in placental mammals after a gene block translocation.

Like other gnathostomes*, placental mammals have: FAM193A< RNF4< CFAP99< ZFYVE28a> MXD4> HAUS3> POLN>

• not seen in zebrafish and osteichthyes who have moved zfyve28

GeneID: 777615 ZDB-GENE-061103-208 NM_001077723.1:NP_001071191.1 seems to be the lone zfyve28 gene in zebrafish.

non-placental gnathostomes* also have: DOK3< DDX41< FAM193B< ZFYVE28b> MXD3> PRELID1< RAB24>

• not found in zebrafish and teleosts who have likely lost ZFYVE28b

placental mammals have: FAM193B> DDX41> DOX3> /many genes/ SLC34A1< RGS14< LMAN2> ZFYVE28b> MXD3> PRELID1< RAB24>