Chymostatin - Revision history

imported>Kevin at 19:36, 2 June 2015

2015-06-02T19:36:29Z

← Older revision		Revision as of 19:36, 2 June 2015
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	Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)		Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)
	[[File:chymostatin.png\|frame\|right\|Chymostatin structure, photo from Sigma-Aldrich]]		[[File:chymostatin.png\|frame\|right\|Chymostatin structure, photo from Sigma-Aldrich]]

	==Suppliers==		==Suppliers==
	*[https://www.caymanchem.com/app/template/Product.vm/catalog/15114 Cayman]		*[https://www.caymanchem.com/app/template/Product.vm/catalog/15114 Cayman]
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	==References==		==References==
			*[https://pubchem.ncbi.nlm.nih.gov/compound/443119 PubChem]
	*[http://www.xenbase.org/literature/article.do?method=display&articleId=16255 Tian et al., 1997]		*[http://www.xenbase.org/literature/article.do?method=display&articleId=16255 Tian et al., 1997]

imported>Kevin at 13:53, 1 June 2015

2015-06-01T13:53:31Z

← Older revision		Revision as of 13:53, 1 June 2015
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	>464 Xenbase articles contain a reference to chymostatin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]		>464 Xenbase articles contain a reference to chymostatin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
			*
			*[[Small Molecules for Xenopus Research\|Back To Small Molecules Home Page]]

imported>Kevin at 18:07, 28 May 2015

2015-05-28T18:07:04Z

← Older revision		Revision as of 18:07, 28 May 2015
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	*[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore]		*[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore]
	*[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en&region=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma]		*[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en&region=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma]
			**Genes Affected
			**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5953470 stsg]

	==Usage Notes==		==Usage Notes==

imported>Kevin at 18:04, 28 May 2015

2015-05-28T18:04:30Z

← Older revision		Revision as of 18:04, 28 May 2015
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	"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."		"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."
	**-Santa Cruz product description		**-Santa Cruz product description
	~~[[File:chymostatin.png\|frame\|right\|Chymostatin structure, photo from Sigma-Aldrich]]~~


	Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)		Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)
			[[File:chymostatin.png\|frame\|right\|Chymostatin structure, photo from Sigma-Aldrich]]
	==Suppliers==		==Suppliers==
	*[https://www.caymanchem.com/app/template/Product.vm/catalog/15114 Cayman]		*[https://www.caymanchem.com/app/template/Product.vm/catalog/15114 Cayman]

imported>Kevin: Created page with "==Description== "Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50..."

2015-05-28T18:03:37Z

Created page with "==Description== "Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50..."

New page

==Description==
"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."
**-Santa Cruz product description
[[File:chymostatin.png|frame|right|Chymostatin structure, photo from Sigma-Aldrich]]

Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)

==Suppliers==
*[https://www.caymanchem.com/app/template/Product.vm/catalog/15114 Cayman]
*[http://www.scbt.com/datasheet-202541-chymostatin.html Santa Cruz]
*[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore]
*[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en&region=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma]

==Usage Notes==

==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=16255 Tian et al., 1997]

>464 Xenbase articles contain a reference to chymostatin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]