Ex-527 - Revision history

imported>Kevin at 19:44, 2 June 2015

2015-06-02T19:44:38Z

← Older revision		Revision as of 19:44, 2 June 2015
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	==References==		==References==
			*[https://pubchem.ncbi.nlm.nih.gov/compound/5113032 PubChem]
	*[http://www.xenbase.org/literature/article.do?method=display&articleId=49378 Ohata et al., 2014]		*[http://www.xenbase.org/literature/article.do?method=display&articleId=49378 Ohata et al., 2014]

	>Search for other articles using EX-527 with [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]		>Search for other articles using EX-527 with [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
	*[[Small Molecules for Xenopus Research\|Back To Small Molecules Home Page]]		*[[Small Molecules for Xenopus Research\|Back To Small Molecules Home Page]]

imported>Kevin at 13:50, 1 June 2015

2015-06-01T13:50:03Z

← Older revision		Revision as of 13:50, 1 June 2015
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	>Search for other articles using EX-527 with [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]		>Search for other articles using EX-527 with [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
			*[[Small Molecules for Xenopus Research\|Back To Small Molecules Home Page]]

imported>Kevin at 21:05, 28 May 2015

2015-05-28T21:05:40Z

← Older revision		Revision as of 21:05, 28 May 2015
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	"EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive."		"EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive."
	**-Sigma Description		**-Sigma Description

			"Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents."
			**-Tocris description

	[[File:EX527.png\|frame\|right\|Ex-527 structure, photo from Sigma-Aldrich]]		[[File:EX527.png\|frame\|right\|Ex-527 structure, photo from Sigma-Aldrich]]
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	==Genes Affected==		==Genes Affected==
	*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=989002 sirt1]		*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=989002 sirt1]
	*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=987374 sirt2]
	*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=990388 sirt3.1]
	*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5721493 sirt3.2]
	*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5929104 sirt6]		*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5929104 sirt6]
	*HDAC

	==Suppliers==		==Suppliers==

imported>Kevin: /* Suppliers */

2015-05-28T21:04:05Z

Suppliers

← Older revision		Revision as of 21:04, 28 May 2015
Line 16:		Line 16:
	*[http://www.sigmaaldrich.com/catalog/product/sigma/e7034?lang=en&region=US Sigma e7034]		*[http://www.sigmaaldrich.com/catalog/product/sigma/e7034?lang=en&region=US Sigma e7034]
	*[http://www.selleckchem.com/products/EX-527.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlkmCpwJ2CFoS79fcsGxIJC8wm4FlXMKAzU8yN1-KfkRoCjSjw_wcB Selleck S1541]		*[http://www.selleckchem.com/products/EX-527.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlkmCpwJ2CFoS79fcsGxIJC8wm4FlXMKAzU8yN1-KfkRoCjSjw_wcB Selleck S1541]
	*[http://www.abcam.com/EX-527-ab141506.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvldL9GZDZxp1g2z0yx0KZie-axeE-blvueltbr35eIzBoChtrw_wcB Abcam ab141506		*[http://www.abcam.com/EX-527-ab141506.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvldL9GZDZxp1g2z0yx0KZie-axeE-blvueltbr35eIzBoChtrw_wcB Abcam ab141506]
	*[http://reactionbiology-com.3dcartstores.com/EX-527_p_329.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlwg7xuMkGe18trwHcvww-MMxwAFuhSm-pcMzwi_LESBoCqVHw_wcB Reaction EI-SRT-006]		*[http://reactionbiology-com.3dcartstores.com/EX-527_p_329.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlwg7xuMkGe18trwHcvww-MMxwAFuhSm-pcMzwi_LESBoCqVHw_wcB Reaction EI-SRT-006]
	*[http://www.tocris.com/dispprod.php?ItemId=85010#.VWd_b9LBzRY Tocris 2780]		*[http://www.tocris.com/dispprod.php?ItemId=85010#.VWd_b9LBzRY Tocris 2780]


	==Usage Notes==		==Usage Notes==

imported>Kevin: Created page with "==Description== "EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) fo..."

2015-05-28T21:02:55Z

Created page with "==Description== "EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) fo..."

New page

==Description==
"EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive."
**-Sigma Description

[[File:EX527.png|frame|right|Ex-527 structure, photo from Sigma-Aldrich]]

==Genes Affected==
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=989002 sirt1]
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=987374 sirt2]
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=990388 sirt3.1]
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5721493 sirt3.2]
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5929104 sirt6]
*HDAC

==Suppliers==
*[http://www.sigmaaldrich.com/catalog/product/sigma/e7034?lang=en&region=US Sigma e7034]
*[http://www.selleckchem.com/products/EX-527.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlkmCpwJ2CFoS79fcsGxIJC8wm4FlXMKAzU8yN1-KfkRoCjSjw_wcB Selleck S1541]
*[http://www.abcam.com/EX-527-ab141506.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvldL9GZDZxp1g2z0yx0KZie-axeE-blvueltbr35eIzBoChtrw_wcB Abcam ab141506
*[http://reactionbiology-com.3dcartstores.com/EX-527_p_329.html?gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlwg7xuMkGe18trwHcvww-MMxwAFuhSm-pcMzwi_LESBoCqVHw_wcB Reaction EI-SRT-006]
*[http://www.tocris.com/dispprod.php?ItemId=85010#.VWd_b9LBzRY Tocris 2780]

==Usage Notes==

==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=49378 Ohata et al., 2014]

>Search for other articles using EX-527 with [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]