https://wiki.xenbase.org/xenwiki/index.php?action=history&feed=atom&title=Hydroxyurea 2026-09-23T20:01:50Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wiki.xenbase.org/xenwiki/index.php?title=Hydroxyurea&diff=48396&oldid=prev 2016-08-09T13:42:44Z

<p>Created page with &quot;==Description== Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enz...&quot;</p> <p><b>New page</b></p><div>==Description==<br /> Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.[http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&amp;ns=NCI_Thesaurus&amp;code=C560]<br /> [[File:Hydroxyureal.structure.png|frame|right|Hydroxyurea structure, image from NCBI Pubchem]] <br /> ==Alternative Names== <br /> * Hydroxycarbamide<br /> * N-Hydroxyurea<br /> * Hydrea<br /> * Onco-carbide<br /> ==Chemical Name==<br /> Hydroxyurea<br /> ==Suppliers==<br /> [http://www.sigmaaldrich.com/catalog/product/sigma/h8627? Sigma]<br /> <br /> ==References==<br /> *[http://www.xenbase.org/literature/article.do?articleId=44961&amp;method=display| &#039;&#039;Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.&#039;&#039; Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.]<br /> *National Center for Biotechnology Information. PubChem Compound Database; CID=3657, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3657]</div>

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