IBMX - Revision history

imported>Kevin at 19:48, 2 June 2015

2015-06-02T19:48:58Z

← Older revision		Revision as of 19:48, 2 June 2015
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	==References==		==References==
			*[https://pubchem.ncbi.nlm.nih.gov/compound/3758 PubChem]
	*[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999]		*[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999]

imported>Kevin at 15:32, 1 June 2015

2015-06-01T15:32:46Z

← Older revision		Revision as of 15:32, 1 June 2015
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	Phosphodiesterase inhibitor.		Phosphodiesterase inhibitor.

	"Biochem/physiol Actions		"Biochem/physiol Actions: Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."

	Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."
	*-Sigma Product Description		*-Sigma Product Description
	[[File:IBMX.png\|frame\|right\|IBMX structure, photo from Sigma-Aldrich]]		[[File:IBMX.png\|frame\|right\|IBMX structure, photo from Sigma-Aldrich]]

imported>Kevin: Created page with "==Description== Phosphodiesterase inhibitor. "Biochem/physiol Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of p..."

2015-06-01T15:27:20Z

Created page with "==Description== Phosphodiesterase inhibitor. "Biochem/physiol Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of p..."

New page

==Description==
Phosphodiesterase inhibitor.

"Biochem/physiol Actions

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."
*-Sigma Product Description
[[File:IBMX.png|frame|right|IBMX structure, photo from Sigma-Aldrich]]

==Genes Affected==

==Suppliers==
*[http://www.tocris.com/dispprod.php?ItemId=5345#.VWx399JVhBc Tocris 2845]
*[https://www.caymanchem.com/app/template/Product.vm/catalog/13347 Cayman 13347]
*[http://www.scbt.com/datasheet-201188-ibmx.html Santa Cruz sc-201188]
*[http://www.enzolifesciences.com/BML-PD140/ibmx/ Enzo]
*[https://www.lifetechnologies.com/order/catalog/product/PHZ1124 Life Technologies PHZ1124]
*[http://www.abcam.com/ibmx-ab120840.html Abcam ab120840]
*[http://www.sigmaaldrich.com/catalog/product/sigma/i5879?lang=en&region=US Sigma-Aldrich i5879]

==Usage Notes==
1mM

==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999]

>452 Xenbase articles contain a reference to IMBX according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]