XB-FEAT-1016002 - Revision history

imported>Xenbase at 16:50, 10 May 2018

2018-05-10T16:50:13Z

← Older revision		Revision as of 16:50, 10 May 2018
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	=summary from NCBI=		=summary from NCBI=
	The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]		The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

			=nomenclature changes=
			05.01.18

			Human name has changed for Entrez Gene: 865. From core-binding factor beta subunit to core-binding factor subunit beta

imported>Xenbase: /* cbfb */

2017-06-30T08:17:00Z

cbfb

← Older revision		Revision as of 08:17, 30 June 2017
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	==In situ preparation note==		==In situ preparation note==
	Several of the community submitted images from the [http://www.xenbase.org/community/lab.do?method=display&labId=352 Patient lab] for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB).		Several of the community submitted images from the [http://www.xenbase.org/community/lab.do?method=display&labId=352 Patient lab] for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB).

			=summary from NCBI=
			The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

imported>Mfisher: Added note on preparation of cleared embryos

2016-04-08T15:25:01Z

Added note on preparation of cleared embryos

← Older revision		Revision as of 15:25, 8 April 2016
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	=cbfb=		=cbfb=
	This is the community wiki page for the gene ''cbfb'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''cbfb'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
			==In situ preparation note==
			Several of the community submitted images from the [http://www.xenbase.org/community/lab.do?method=display&labId=352 Patient lab] for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB).

imported>Xenbase gene generator at 12:00, 10 February 2010

2010-02-10T12:00:00Z

New page

=cbfb=
This is the community wiki page for the gene ''cbfb'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase