XB-FEAT-1221158 - Revision history

Christina: /* nomenclature changes */

2023-06-07T15:20:15Z

nomenclature changes

← Older revision		Revision as of 15:20, 7 June 2023
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	SYNONYMS: TTC30B, FLJ30990, fleer		SYNONYMS: TTC30B, FLJ30990, fleer

			05JUNE 2023

			‘’Xenopus’’ symbol has changed for XB-GENEPAGE-1221158. From ttc30a to ift70a

			Human symbol has changed for Entrez Gene: 92104. From TTC30A to IFT70A

			Human name has changed for Entrez Gene: 92104. From tetratricopeptide repeat domain 30A to intraflagellar transport 70A

	=orthology & synteny=		=orthology & synteny=

Christina: /* ift70 */

2023-06-07T15:19:22Z

ift70

← Older revision		Revision as of 15:19, 7 June 2023
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	=''~~ift70~~''=		=''ift70a''=
	This is the community wiki page for the gene ''~~ift70~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''ift70a'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

	=nomenclature changes=		=nomenclature changes=

Christina: /* orthology & synteny */

2023-05-24T17:26:18Z

orthology & synteny

Show changes

Christina: /* nomenclature changes */

2023-05-24T17:18:37Z

nomenclature changes

← Older revision		Revision as of 17:18, 24 May 2023
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	GENE NAME: intraflagellar transport 70B		GENE NAME: intraflagellar transport 70B
	SYNONYMS: TTC30B, FLJ30990, fleer		SYNONYMS: TTC30B, FLJ30990, fleer


			=orthology & synteny=

			from David Web at NCBi ref-Seq:

			* TTC30 genes of mammals appear to be a single-exon retrotransposed copy of the ancestral multi-exon TTC30 gene. Plus, the location of the mammalian retrotransposed gene differs from the ancestral gene. The retrotransposition, and loss of the ancestral gene, possibly happened in amniotes and then it got duplicated once in placental mammals to make TTC30a/b and duplicated again somewhere in rodents.

			* confirmed, by synteny and BLASTp, that the ancestral gnathostome multi-exon TTC30 gene was (likely) retrotransposed in amniotes to a new location as a single-exon gene. See the attached word doc TTC30.docx for the synteny evolution with two tandem TTC30 genes in placental mammals and three tandem TTC30 genes in most rodents. A minimum evolution tree of aligned proteins confirms that non-placental gnathostomes have just one TTC30 encoding gene, placentals have two and most rodents three TTC30 genes (tree not shown).

			* In mammals there's a notable absence of gene annotation in the region where the amphibian TTC30 gene resides between TMEM108< and NPHP3>but tBLASTn and other alignment attempts failed to find any relict of the TTC30 gene in amniotes (nor could I find a relict of TTC30 near GSG1L or C16orf89 in amniotes).

			* So, I suggest the single gene in fish, amphibians, and reptiles/birds be called simply IFT70

			* IFT70A and IFT70B should be used only for placental mammals.

Christina: /* ift70a */

2023-05-24T17:15:10Z

ift70a

← Older revision		Revision as of 17:15, 24 May 2023
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	=''~~ift70a~~''=		=''ift70''=
	This is the community wiki page for the gene ''~~ift70a~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''ift70'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

	=nomenclature changes=		=nomenclature changes=

Christina: /* nomenclature changes */

2023-02-27T19:40:48Z

nomenclature changes

← Older revision		Revision as of 19:40, 27 February 2023
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	THE HGNC, after a request from some of our specialist advisors and a consultation with authors publishing on these genes , have updated the nomenclature of three flagellar transport genes in human as follows: from TTCP26 , tetratricopeptide repeat domain 26 to IFT56, intraflagellar transport 56. This is now more functionally informative and in line with their ''Chlamydomonas'' orthologs.		THE HGNC, after a request from some of our specialist advisors and a consultation with authors publishing on these genes , have updated the nomenclature of three flagellar transport genes in human as follows: from TTCP26 , tetratricopeptide repeat domain 26 to IFT56, intraflagellar transport 56. This is now more functionally informative and in line with their ''Chlamydomonas'' orthologs.

	''Xenopus'' gene names follow that of human, so the ''Xenopus'' gene name has also changed from ''~~ttc30a~~'' , tetratricopeptide repeat domain ~~30 a~~ to ''~~ift70a~~'', intraflagellar transport ~~70a~~.		''Xenopus'' gene names follow that of human, so the ''Xenopus'' gene name has also changed from ''ttcp26'' , tetratricopeptide repeat domain 26 to ''ift56'', intraflagellar transport 56.

	Note the 3 genes in this group are now have the following synonyms:		Note the 3 Human genes in this group are now have the following synonyms, although IFT70B does not seem to have an ortholog in ''Xenopus'':

	GENE SYMBOL: IFT56		GENE SYMBOL: IFT56

Christina: /* ift70a */

2023-02-27T17:51:35Z

ift70a

← Older revision		Revision as of 17:51, 27 February 2023
Line 1:		Line 1:
	=ift70a=		=''ift70a''=
	This is the community wiki page for the gene ''ift70a'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''ift70a'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

Christina: /* ift70a */

2023-02-27T17:51:25Z

ift70a

← Older revision		Revision as of 17:51, 27 February 2023
Line 1:		Line 1:
	=~~ttc30~~=		=ift70a=
	This is the community wiki page for the gene ''~~ttc30~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''ift70a'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

			=nomenclature changes=
			27FEB2023

			THE HGNC, after a request from some of our specialist advisors and a consultation with authors publishing on these genes , have updated the nomenclature of three flagellar transport genes in human as follows: from TTCP26 , tetratricopeptide repeat domain 26 to IFT56, intraflagellar transport 56. This is now more functionally informative and in line with their ''Chlamydomonas'' orthologs.

			''Xenopus'' gene names follow that of human, so the ''Xenopus'' gene name has also changed from ''ttc30a'' , tetratricopeptide repeat domain 30 a to ''ift70a'', intraflagellar transport 70a.

			Note the 3 genes in this group are now have the following synonyms:

			GENE SYMBOL: IFT56
			GENE NAME: intraflagellar transport 56
			SYNONYMS: TTC26, FLJ12571, dyf-13, DYF13

			GENE SYMBOL: IFT70A
			GENE NAME: intraflagellar transport 70A
			SYNONYMS: TTC30A, FLJ13946, FAP259, CFAP259

			GENE SYMBOL: IFT70B
			GENE NAME: intraflagellar transport 70B
			SYNONYMS: TTC30B, FLJ30990, fleer

imported>Xenbase gene generator at 12:00, 10 February 2010

2010-02-10T12:00:00Z

New page

=ttc30=
This is the community wiki page for the gene ''ttc30'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase