XB-FEAT-22041727 - Revision history

Christina: /* nomenclature changes */

2023-04-25T18:34:06Z

nomenclature changes

← Older revision		Revision as of 18:34, 25 April 2023
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	This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
	=nomenclature changes=		=nomenclature changes=
	name changed from ''XB22041727'' to ''dact4'' following description of this new gene and its phylogentic relationships in ~~eth~~ dapper family of genes by Gabriele Colozza and Eddy De Robertis, see ''Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins'', Gene Expression Patterns, 2020. [https://doi.org/10.1016/j.gep.2020.119153]		name changed from ''XB22041727'' to ''dact4'' following description of this new gene and its phylogentic relationships in the 'dapper' family of genes by Gabriele Colozza and Eddy De Robertis, see ''Dact-4 is a ''Xenopus laevis'' Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins'', Gene Expression Patterns, 2020. [https://doi.org/10.1016/j.gep.2020.119153]

	=summary from Colozza and De Robertis 2020 for human DACT family genes=		=summary from Colozza and De Robertis 2020 for human DACT family genes=

imported>Xenbase: /* summary from Colozza and De Robertis 2020 for human DACT family genes */

2020-12-07T14:12:10Z

summary from Colozza and De Robertis 2020 for human DACT family genes

← Older revision		Revision as of 14:12, 7 December 2020
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	Dact/Dapper/Frodo members belong to an evolutionarily conserved family of Dishevelled-binding proteins present in mammals, birds, amphibians and fishes that are involved in the regulation of Wnt and TGF-β signaling. In addition to the three established genes (Dact1-3) that compose the Dact family, a fourth paralogue group of related proteins has been recently identified and named Dact-4. Interestingly, Dact-4 [''dact4''] is the most rapidly evolving gene of the entire family, as it displays very low homology with other Dact proteins and has lost key conserved domains. Dact-4 is not present in mammals, but weakly conserved homologs were found in reptiles and fishes.		Dact/Dapper/Frodo members belong to an evolutionarily conserved family of Dishevelled-binding proteins present in mammals, birds, amphibians and fishes that are involved in the regulation of Wnt and TGF-β signaling. In addition to the three established genes (Dact1-3) that compose the Dact family, a fourth paralogue group of related proteins has been recently identified and named Dact-4. Interestingly, Dact-4 [''dact4''] is the most rapidly evolving gene of the entire family, as it displays very low homology with other Dact proteins and has lost key conserved domains. Dact-4 is not present in mammals, but weakly conserved homologs were found in reptiles and fishes.

	Depletion of ''dact1'' mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.		From NCBI summary for DACT1: Depletion of ''dact1'' mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.

	Note that ''Xenopus dact4'' does not have any mammalian orthologs.		Note that ''Xenopus dact4'' does not have any mammalian orthologs.

imported>Xenbase: /* summary from NCBI for human DACT family genes */

2020-12-07T14:11:17Z

summary from NCBI for human DACT family genes

← Older revision		Revision as of 14:11, 7 December 2020
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	name changed from ''XB22041727'' to ''dact4'' following description of this new gene and its phylogentic relationships in eth dapper family of genes by Gabriele Colozza and Eddy De Robertis, see ''Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins'', Gene Expression Patterns, 2020. [https://doi.org/10.1016/j.gep.2020.119153]		name changed from ''XB22041727'' to ''dact4'' following description of this new gene and its phylogentic relationships in eth dapper family of genes by Gabriele Colozza and Eddy De Robertis, see ''Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins'', Gene Expression Patterns, 2020. [https://doi.org/10.1016/j.gep.2020.119153]

	=summary from ~~NCBI~~ for human DACT family genes=		=summary from Colozza and De Robertis 2020 for human DACT family genes=
	~~The protein [family] encoded by these genes~~ belong to ~~the '''dapper'''~~ family, ~~characterized by~~ the ~~presence~~ of ~~PDZ~~-~~binding motif at~~ the C-~~terminus. They interacts with~~, and ~~positively regulate dishevelled~~-~~mediated signaling pathways during development~~. ~~Depletion~~ of ~~DACT1 mRNA from Xenopus embryos resulted~~ in ~~loss of notochord and head structures~~, and ~~mice lacking the DACT1 gene died shortly after birth from severe posterior malformations~~.		Dact/Dapper/Frodo members belong to an evolutionarily conserved family of Dishevelled-binding proteins present in mammals, birds, amphibians and fishes that are involved in the regulation of Wnt and TGF-β signaling. In addition to the three established genes (Dact1-3) that compose the Dact family, a fourth paralogue group of related proteins has been recently identified and named Dact-4. Interestingly, Dact-4 [''dact4''] is the most rapidly evolving gene of the entire family, as it displays very low homology with other Dact proteins and has lost key conserved domains. Dact-4 is not present in mammals, but weakly conserved homologs were found in reptiles and fishes.

	Note that ''Xenopus dact4'' does not have ~~a human ortholog~~.		Depletion of ''dact1'' mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.
			Note that ''Xenopus dact4'' does not have any mammalian orthologs.

imported>Xenbase: /* summary from NCBI for human DACT family genes */

2020-12-07T14:08:38Z

summary from NCBI for human DACT family genes

← Older revision		Revision as of 14:08, 7 December 2020
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	=summary from NCBI for human DACT family genes=		=summary from NCBI for human DACT family genes=
	The protein [family] encoded by ~~thiesegene~~ belong to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. They interacts with, and positively regulate dishevelled-mediated signaling pathways during development. Depletion of DACT1 mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.		The protein [family] encoded by these genes belong to the '''dapper''' family, characterized by the presence of PDZ-binding motif at the C-terminus. They interacts with, and positively regulate dishevelled-mediated signaling pathways during development. Depletion of DACT1 mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.

	Note that ''Xenopus dact4'' does not to have a human ortholog.		Note that ''Xenopus dact4'' does not have a human ortholog.

imported>Xenbase: /* nomenclature changes */

2020-12-07T14:07:53Z

nomenclature changes

← Older revision		Revision as of 14:07, 7 December 2020
Line 2:		Line 2:
	This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
	=nomenclature changes=		=nomenclature changes=
	name changed from XB to ''dact4''		name changed from ''XB22041727'' to ''dact4'' following description of this new gene and its phylogentic relationships in eth dapper family of genes by Gabriele Colozza and Eddy De Robertis, see ''Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins'', Gene Expression Patterns, 2020. [https://doi.org/10.1016/j.gep.2020.119153]

	=summary from NCBI for human DACT family genes=		=summary from NCBI for human DACT family genes=
	The protein [family] encoded by thiesegene belong to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. They interacts with, and positively regulate dishevelled-mediated signaling pathways during development. Depletion of DACT1 mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.		The protein [family] encoded by thiesegene belong to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. They interacts with, and positively regulate dishevelled-mediated signaling pathways during development. Depletion of DACT1 mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.

	Note that ''Xenopus dact4'' does not to have a human ortholog.		Note that ''Xenopus dact4'' does not to have a human ortholog.

imported>Xenbase: Created page with "=''dact4''= This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere..."

2020-12-07T14:05:08Z

Created page with "=''dact4''= This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere..."

New page

=''dact4''=
This is the community wiki page for the gene ''dact4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
=nomenclature changes=
name changed from XB to ''dact4''
=summary from NCBI for human DACT family genes=
The protein [family] encoded by thiesegene belong to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. They interacts with, and positively regulate dishevelled-mediated signaling pathways during development. Depletion of DACT1 mRNA from Xenopus embryos resulted in loss of notochord and head structures, and mice lacking the DACT1 gene died shortly after birth from severe posterior malformations.

Note that ''Xenopus dact4'' does not to have a human ortholog.