XB-FEAT-480286 - Revision history

Christina: /* il12b */

2023-05-09T14:10:36Z

il12b

← Older revision		Revision as of 14:10, 9 May 2023
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	=''il12b''=		=''il12b''=
	This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

			=summary for human IL12B from NCBI=
			IL12B - interleukin 12B

			This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

	=synteny of ''il12b'' and ''il12b-like'' across vertebrates=		=synteny of ''il12b'' and ''il12b-like'' across vertebrates=

Christina: /* synteny fof il12b and il12b-like across vertebrates */

2023-03-10T15:01:56Z

synteny fof il12b and il12b-like across vertebrates

← Older revision		Revision as of 15:01, 10 March 2023
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	This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

	=synteny ~~fof~~ ''il12b'' and ''il12b-like'' across vertebrates=		=synteny of ''il12b'' and ''il12b-like'' across vertebrates=

	source: David Webb, NCBI RefSEQ team		source: David Webb, NCBI RefSEQ team

Christina: /* synteny fof il12b and il12b-like across vertebrates */

2023-02-21T18:58:35Z

synteny fof il12b and il12b-like across vertebrates

← Older revision		Revision as of 18:58, 21 February 2023
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	source: David Webb, NCBI RefSEQ team		source: David Webb, NCBI RefSEQ team

	Here's the synteny of '''IL12B''': ( taxa, protein accession)
			'''Here's the synteny of '''IL12B''':''' ( taxa, protein accession)


	Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1:		Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1:
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	'''Here's the synteny of '''IL12B-like''' that is lost in mammals:'''		'''Here's the synteny of '''IL12B-like''' that is lost in mammals:'''


	Gallus GeneID:101747944 XP_025006217.3		Gallus GeneID:101747944 XP_025006217.3
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	LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< dock2> insyn2b<		LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< dock2> insyn2b<


	Podarcis muralis		Podarcis muralis

	LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< insyn2b< bnip3L< AUP1< HTRA2>		LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< insyn2b< bnip3L< AUP1< HTRA2>


	Xtr GeneID: 100493914 XP_031750962.1		Xtr GeneID: 100493914 XP_031750962.1

	TLX2> mmp21< '''il12b-like'''< DQX1< AUP1< HTRA2>		TLX2> mmp21< '''il12b-like'''< DQX1< AUP1< HTRA2>


	gar XP_015215443.1		gar XP_015215443.1

	TLX2> npm-like> fgf18L> PCGF1>// '''il12b-like<''' dqx1< avp<		TLX2> npm-like> fgf18L> PCGF1>// '''il12b-like<''' dqx1< avp<


	skate XP_032900156.1		skate XP_032900156.1

	//'''il12b-like<''' DQX1< DOCK2L> insyn2b< bnip3L< AUP1<		//'''il12b-like<''' DQX1< DOCK2L> insyn2b< bnip3L< AUP1<

	mammals		mammals
	LBX2< PCGF1< TLX2> DQX1< AUP1< HTRA2>		LBX2< PCGF1< TLX2> DQX1< AUP1< HTRA2> (missing!)

Christina: /* synteny fof il12b and il12b-like across vertebrates */

2023-02-21T18:57:24Z

synteny fof il12b and il12b-like across vertebrates

← Older revision		Revision as of 18:57, 21 February 2023
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	This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

	=synteny fof '''il12b''' and ''il12b-like'' across vertebrates=		=synteny fof ''il12b'' and ''il12b-like'' across vertebrates=

	source: David Webb, NCBI RefSEQ team		source: David Webb, NCBI RefSEQ team

	Here's the synteny of IL12B: ( taxa protein accession)		Here's the synteny of '''IL12B''': ( taxa, protein accession)

	Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1:		Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1:

Christina: /* il12b */

2023-02-21T18:56:53Z

il12b

← Older revision		Revision as of 18:56, 21 February 2023
Line 1:		Line 1:
	=il12b=		=''il12b''=
	This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

			=synteny fof '''il12b''' and ''il12b-like'' across vertebrates=

			source: David Webb, NCBI RefSEQ team

			Here's the synteny of IL12B: ( taxa protein accession)

			Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1:

			EBF1< RNF145< UBLCP1> '''IL12B'''< LOCs>>> ADRA1B> TTC1> PWWP2A<


			Gallus NP_998736.1, emu XP_025974440.1, crocodile XP_019390924:

			FBXO38< spink-like< '''IL12B'''< LOCs> ADRA1B> TTC1> PWWP2A<


			C.midas XP_007057329.3

			FBXO38< spink-like< spink-like< '''IL12B'''< ADRA1B> TTC1> PWWP2A<


			P. muralis XP_028576963.1

			FBXO38< spink-like< spink-like> '''IL12B'''< KCNIP1< KCNMB1>


			Xtr XP_031754537.1

			EBF4< RNF145< UBLCP1> mmp21-like< '''IL12B'''< ADRA1B> havcr1-like< havcr1-like<


			protopterus XP_043925850.1

			ebf1< RNF145< UBLCP1> mmp21-like< '''IL12B'''< [unannotated region]


			gar XP_006631788.2, sterlet XP_033907726.1

			EBF1< RNF145< UBLCP1> mmp21-like< '''IL12B'''< EFCAB9> UBTD2<


			skate XP_032885430.1 (note downstream synteny to IL12B-like)

			ADAM19> UBLCP1> mmp21-like< '''IL12B'''< DOCK2> INSYN2B


			D.rerio GeneID: 445373 (il12ba) ZDB-GENE-050525-3 & GeneID:335994 (il12bb) ZDB-GENE-030131-7937?


			EBF1a< RNF145a< '''IL12Ba'''< ADRB2A> SH3TC2<

			RARS< UBLCP1> '''IL12Bb'''< UBTD2< ADRB2b>


			'''Here's the synteny of '''IL12B-like''' that is lost in mammals:'''

			Gallus GeneID:101747944 XP_025006217.3

			LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< dock2> insyn2b< bnip3L< AUP1< HTRA2>


			Chelonia mydas

			LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< dock2> insyn2b<

			Podarcis muralis

			LBX2< PCGF1< TLX2> nefll> '''il12b-like<''' DQX1< insyn2b< bnip3L< AUP1< HTRA2>

			Xtr GeneID: 100493914 XP_031750962.1

			TLX2> mmp21< '''il12b-like'''< DQX1< AUP1< HTRA2>

			gar XP_015215443.1

			TLX2> npm-like> fgf18L> PCGF1>// '''il12b-like<''' dqx1< avp<

			skate XP_032900156.1

			//'''il12b-like<''' DQX1< DOCK2L> insyn2b< bnip3L< AUP1<

			mammals
			LBX2< PCGF1< TLX2> DQX1< AUP1< HTRA2>

imported>Xenbase gene generator at 12:00, 10 February 2010

2010-02-10T12:00:00Z

New page

=il12b=
This is the community wiki page for the gene ''il12b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase