XB-FEAT-5812346 - Revision history

Christina: /* spata18b */

2023-04-29T15:19:42Z

spata18b

← Older revision		Revision as of 15:19, 29 April 2023
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	=spata18b=		=''spata18b''=
	This is the community wiki page for the gene ''spata18b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''spata18b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

Christina: /* nomenclature changes */

2022-09-20T15:58:23Z

nomenclature changes

← Older revision		Revision as of 15:58, 20 September 2022
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	2020/06/04		2020/06/04

	~~2020/06/04~~
	Human symbol has changed for genepage ID: 5812346 From spata18b to SPATA18- DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human SPATA18.		Human symbol has changed for genepage ID: 5812346 From spata18b to SPATA18- DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human SPATA18.

	Human symbol has changed for genepage ID: 22172606 From spata18a to SPATA18-DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human SPATA18.		Human symbol has changed for genepage ID: 22172606 From spata18a to SPATA18-DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human SPATA18.

imported>Xenbase: /* nomenclature changes */

2020-07-07T22:16:00Z

nomenclature changes

← Older revision		Revision as of 22:16, 7 July 2020
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	2020/06/04		2020/06/04

	Human symbol has changed for genepage ID: 5812346 From spata18b to SPATA18- DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human ~~spata18~~.		2020/06/04
			Human symbol has changed for genepage ID: 5812346 From spata18b to SPATA18- DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human SPATA18.

			Human symbol has changed for genepage ID: 22172606 From spata18a to SPATA18-DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human SPATA18.

imported>Xenbase: /* nomenclature changes */

2020-07-07T20:17:11Z

nomenclature changes

← Older revision		Revision as of 20:17, 7 July 2020
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	Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.		Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.

	Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and "gene 2'' which is used for tandem duplications.		Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and ''gene 2'' which is used for tandem duplications.

imported>Xenbase: /* nomenclature changes */

2020-06-09T20:24:23Z

nomenclature changes

← Older revision		Revision as of 20:24, 9 June 2020
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	Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and "gene 2'' which is used for tandem duplications.		Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and "gene 2'' which is used for tandem duplications.



			2020/06/04

			Human symbol has changed for genepage ID: 5812346 From spata18b to SPATA18- DO NOT change on Xenbase gene page as we have the a and b duplications, and both are orthologous to human spata18.

imported>Xenbase: /* nomenclature changes */

2020-01-13T17:01:21Z

nomenclature changes

← Older revision		Revision as of 17:01, 13 January 2020
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	b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> also on Chromosome 3 (which we now call ''spata18a'')		b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> also on Chromosome 3 (which we now call ''spata18a'')

	So it appears that an ancestor to X.~~tropidalis~~ and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" genes.		So it appears that an ancestor to X.tropicalis and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" genes.

	Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.		Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.

	Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and "gene 2'' which is used for tandem duplications.		Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and "gene 2'' which is used for tandem duplications.

imported>Xenbase: /* nomenclature changes */

2020-01-02T16:58:12Z

nomenclature changes

← Older revision		Revision as of 16:58, 2 January 2020
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	The gene name and symbol was changed from ''spata18.2'' to ''spata18b'' to reflect information gained from a review of these genes by David Webb at NCBI. [details follow]		The gene name and symbol was changed from ''spata18.2'' to ''spata18b'' to reflect information gained from a review of these genes by David Webb at NCBI. [details follow]

	Going at least as far back as gnathostomes ( including ''Nanorana parkeri'' and caecillians ''Rhinatrema bivittatum'' and ''Microcaecaecilia unicolor''), the SPATA18 gene has resided ina conserved region [with this gene order]:		Going at least as far back as gnathostomes ( including ''Nanorana parkeri'' and caecillians ''Rhinatrema bivittatum'' and ''Microcaecaecilia unicolor''), the SPATA18 gene has resided ina conserved region with this gene order:

	DCUN1D4> ... LRRC66< ... SGCB< ... ''''''SPATA18''''''> ... (PSUEDO)GENE< ... USP46< ... DANCR ... RASL11B>		DCUN1D4> ... LRRC66< ... SGCB< ... ''''''SPATA18''''''> ... (PSUEDO)GENE< ... USP46< ... DANCR ... RASL11B>

	However in ''Xenopus'', the "spata18" gene is missing from this location while two other ''spata18'' genes do occur at other locations that are unique to ''Xenopus''!		However in ''Xenopus'', the "spata18" gene is missing from this location, while two other ''spata18'' genes do occur at other locations that are unique to ''Xenopus''!

	These two 'other' regions are well conserved in tetrapods. The regions with these "Xenopus-specific" spata18 ~~gens~~ insertions are:		These two 'other' regions are well conserved in tetrapods. The regions with these "Xenopus-specific" spata18 genes insertions are:

	a) AEBP1> ... POLD2< ... "'''SPATA18'''"> ... MYL7< ... GCK< ... YKT6> on chromosome 3 ( which we now call ''spata18b'')		a) AEBP1> ... POLD2< ... "'''SPATA18'''"> ... MYL7< ... GCK< ... YKT6> on chromosome 3 (which we now call ''spata18b'')

	b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> also on Chromosome 3 ( which we now call ''spata18a'')		b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> also on Chromosome 3 (which we now call ''spata18a'')

	So it appears that an ancestor to X.tropidalis and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" ~~gens~~.		So it appears that an ancestor to X.tropidalis and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" genes.

	Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.		Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.

	Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than '' gene 1'' and "gene 2'' which is used for tandem duplications.		Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than ''gene 1'' and "gene 2'' which is used for tandem duplications.

imported>Xenbase: /* nomenclature changes */

2019-12-31T19:52:41Z

nomenclature changes

← Older revision		Revision as of 19:52, 31 December 2019
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	a) AEBP1> ... POLD2< ... "'''SPATA18'''"> ... MYL7< ... GCK< ... YKT6> on chromosome 3 ( which we now call ''spata18b'')		a) AEBP1> ... POLD2< ... "'''SPATA18'''"> ... MYL7< ... GCK< ... YKT6> on chromosome 3 ( which we now call ''spata18b'')

	b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> . on Chromosome ( which we now call ''spata18a'')		b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> also on Chromosome 3 ( which we now call ''spata18a'')

	So it appears that an ancestor to X.tropidalis and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" gens.		So it appears that an ancestor to X.tropidalis and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" gens.

imported>Xenbase: /* nomenclature changes */

2019-12-31T19:45:41Z

nomenclature changes

← Older revision		Revision as of 19:45, 31 December 2019
Line 3:		Line 3:

	=nomenclature changes=		=nomenclature changes=
	12.31.2019		12.31.2019

	The gene name and symbol was changed from ''spata18.2'' to ''spata18b'' to reflect information gained from a review of these genes by David Webb at NCBI. [details follow]		The gene name and symbol was changed from ''spata18.2'' to ''spata18b'' to reflect information gained from a review of these genes by David Webb at NCBI. [details follow]
Line 23:		Line 23:
	Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.		Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.

	We have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than .1 and.2 which is used for tandem duplications.		Accordingly, we have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than '' gene 1'' and "gene 2'' which is used for tandem duplications.

imported>Xenbase: /* spata18 */

2019-12-31T19:44:25Z

spata18

← Older revision		Revision as of 19:44, 31 December 2019
Line 1:		Line 1:
	=~~spata18~~=		=spata18b=
	This is the community wiki page for the gene ''~~spata18~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''spata18b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

			=nomenclature changes=
			12.31.2019

			The gene name and symbol was changed from ''spata18.2'' to ''spata18b'' to reflect information gained from a review of these genes by David Webb at NCBI. [details follow]

			Going at least as far back as gnathostomes ( including ''Nanorana parkeri'' and caecillians ''Rhinatrema bivittatum'' and ''Microcaecaecilia unicolor''), the SPATA18 gene has resided ina conserved region [with this gene order]:

			DCUN1D4> ... LRRC66< ... SGCB< ... ''''''SPATA18''''''> ... (PSUEDO)GENE< ... USP46< ... DANCR ... RASL11B>

			However in ''Xenopus'', the "spata18" gene is missing from this location while two other ''spata18'' genes do occur at other locations that are unique to ''Xenopus''!

			These two 'other' regions are well conserved in tetrapods. The regions with these "Xenopus-specific" spata18 gens insertions are:

			a) AEBP1> ... POLD2< ... "'''SPATA18'''"> ... MYL7< ... GCK< ... YKT6> on chromosome 3 ( which we now call ''spata18b'')

			b) FBXL13< ... ARMC10> ... NAPELD< "'''SPATA18'''"> ... PMPCB> ... DNAJC2< ... PSMC2> . on Chromosome ( which we now call ''spata18a'')

			So it appears that an ancestor to X.tropidalis and X.laevis LOST the canonical SPATA18 gene locus but also duplicated and translocated 2 "spata18" gens.

			Given that the exon and protein structure of the canonical tetrapod SPATA18 is maintained by these 2 "spata18" genes, we propose that they should be treated as orthologous to human SPATA18, rather than considered "spata18-like" genes.

			We have given them "a" and "b" designations to reflect this duplication of the orthologue, rather than .1 and.2 which is used for tandem duplications.