XB-FEAT-5848002 - Revision history

Xenbase: /* notes on synonyms */

2025-05-14T18:27:16Z

notes on synonyms

← Older revision		Revision as of 18:27, 14 May 2025
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	=notes on synonyms=		=notes on synonyms=
	XB5848002, also known as 'loc100494211', ~~and is referred to as 'Bighead' in this~~ Ding ''et al'' 2018:XB-ART-55302		the genes on XB-genepage-5848002, currently called XB5848002, also known as 'loc100494211', was first described by Ding ''et al'' 2018, in XB-ART-55302, who named it 'Bighead'. As there is no known human ortholog, and the zebrafish gene remains undescribed and unnamed, we have applied the authors name to the ''Xenopus'' genes, and updated the name to 'wnt antagonist XB5848002' for the time-being, giving credit where credit is due.

	=notes on gene function=		=notes on gene function=

Xenbase: /* XB5848002 */

2025-05-14T18:23:28Z

XB5848002

← Older revision		Revision as of 18:23, 14 May 2025
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	= ''~~XB5848002~~'' =		= ''bighead'' =
	This is the community wiki page for the gene ''~~XB5848002~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.		This is the community wiki page for the gene ''bighead'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

	=notes on synonyms=		=notes on synonyms=

imported>Xenbase: /* notes on synonyms */

2020-11-30T19:59:27Z

notes on synonyms

← Older revision		Revision as of 19:59, 30 November 2020
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	=notes on synonyms=		=notes on synonyms=
	XB5848002, also known as 'loc100494211', and is referred to as 'Bighead' in this ~~article. XB-ART-55302~~		XB5848002, also known as 'loc100494211', and is referred to as 'Bighead' in this Ding ''et al'' 2018:XB-ART-55302
	~~''Bighead'' is a Wnt antagonist secreted by the~~ ''~~Xenopus~~'' ~~Spemann organizer that promotes Lrp6 endocytosis~~
	~~Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis~~
	~~PNAS published ahead of print September 12,~~ 2018 ~~https~~:~~//doi.org/10.1073/pnas.1812117115.~~

	When fully characterized, the gene name and synonyms ~~will~~ be updated to reflect what kind of protien/gene family this gene represents.		=notes on gene function=
			''Bighead'' is a Wnt antagonist secreted by the ''Xenopus'' Spemann organizer that promotes Lrp6 endocytosis. It was shown to be conserved in frogs and fishes, but absent in higher vertebrates such as mammals.

			Reference: Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis
			PNAS, 2018 https://doi.org/10.1073/pnas.1812117115.

			When fully characterized, the gene name and synonyms may be updated to reflect what kind of protien/gene family this gene represents, but until then it will probably be known as 'bighead'.

	=protein function and phenotype notes=		=protein function and phenotype notes=

imported>Xenbase: /* XB5848002 */

2020-11-30T19:09:36Z

XB5848002

← Older revision		Revision as of 19:09, 30 November 2020
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	= XB5848002 =		= ''XB5848002'' =
	This is the community wiki page for the gene ''XB5848002'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.		This is the community wiki page for the gene ''XB5848002'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

imported>Xenbase: /* notes on synonyms */

2020-11-30T19:09:23Z

notes on synonyms

← Older revision		Revision as of 19:09, 30 November 2020
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	=notes on synonyms=		=notes on synonyms=
	XB5848002 is also known as 'loc100494211'and is referred to as 'Bighead' in this article. XB-ART-55302		XB5848002, also known as 'loc100494211', and is referred to as 'Bighead' in this article. XB-ART-55302
	''Bighead'' is a Wnt antagonist secreted by the ''Xenopus'' Spemann organizer that promotes Lrp6 endocytosis		''Bighead'' is a Wnt antagonist secreted by the ''Xenopus'' Spemann organizer that promotes Lrp6 endocytosis
	Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis		Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis

imported>Xenbase: /* protein function and phenotype notes */

2020-11-30T19:09:01Z

protein function and phenotype notes

← Older revision		Revision as of 19:09, 30 November 2020
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	=protein function and phenotype notes=		=protein function and phenotype notes=

	Bighead is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6.		''Bighead'' is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6.
	Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling.		Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling.

imported>Xenbase: /* notes on synonyms */

2020-11-30T19:08:37Z

notes on synonyms

← Older revision		Revision as of 19:08, 30 November 2020
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	This is the community wiki page for the gene ''XB5848002'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.		This is the community wiki page for the gene ''XB5848002'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

	=~~synonym~~=		=notes on synonyms=
	loc100494211 referred to as 'Bighead' in this article. XB-ART-55302		XB5848002 is also known as 'loc100494211'and is referred to as 'Bighead' in this article. XB-ART-55302
	Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis		''Bighead'' is a Wnt antagonist secreted by the ''Xenopus'' Spemann organizer that promotes Lrp6 endocytosis
	Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis		Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis
	PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.		PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.

			When fully characterized, the gene name and synonyms will be updated to reflect what kind of protien/gene family this gene represents.

	=protein function and phenotype notes=		=protein function and phenotype notes=

imported>Xenbase: /* XB5848002 */

2020-11-30T19:06:40Z

XB5848002

← Older revision		Revision as of 19:06, 30 November 2020
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	=~~loc100494211~~=		= XB5848002 =
	This is the community wiki page for the gene ''~~loc100494211~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.		This is the community wiki page for the gene ''XB5848002'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

	=synonym=		=synonym=

imported>Xenbase: /* loc100494211 */

2018-09-21T16:15:16Z

loc100494211

← Older revision		Revision as of 16:15, 21 September 2018
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	=loc100494211=		=loc100494211=
	This is the community wiki page for the gene ''loc100494211'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''loc100494211'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

			=synonym=
			loc100494211 referred to as 'Bighead' in this article. XB-ART-55302
			Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis
			Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis
			PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.

			=protein function and phenotype notes=

			Bighead is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6.
			Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling.

			source:
			Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis
			Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis
			PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.

imported>Xenbase: /* loc100494211 */Updated nomenclature, replaced: unnamed → loc100494211 (2)

2017-12-15T21:29:09Z

loc100494211: Updated nomenclature, replaced: unnamed → loc100494211 (2)

← Older revision		Revision as of 21:29, 15 December 2017
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	=~~unnamed~~=		=loc100494211=
	This is the community wiki page for the gene ''~~unnamed~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''loc100494211'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase