XB-FEAT-5866765 - Revision history

imported>Xenbase: /* nomenclature changes */

2020-08-31T15:16:10Z

nomenclature changes

← Older revision		Revision as of 15:16, 31 August 2020
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	named changed (XB-GENE-5866766) from selenoprotein P, plasma, 1 to selenoprotein P1		named changed (XB-GENE-5866766) from selenoprotein P, plasma, 1 to selenoprotein P1

			09DEC2017
	symbol changed (XB-GENE-5866766) from selenop to selenop1		symbol changed (XB-GENE-5866766) from selenop to selenop1

imported>Xenbase: /* selenop1 */

2020-08-31T15:15:24Z

selenop1

← Older revision		Revision as of 15:15, 31 August 2020
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	=~~selenop~~=		=selenop1=
	This is the community wiki page for the gene ''~~selenop~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''selenop1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

	=nomenclature changes=		=nomenclature changes=
	11NOV 2016		11NOV 2016

imported>Xenbase: /* nomenclature changes */

2020-08-31T15:14:39Z

nomenclature changes

← Older revision		Revision as of 15:14, 31 August 2020
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	This is the community wiki page for the gene ''selenop'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''selenop'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
	=nomenclature changes=		=nomenclature changes=
	11NOV 2016		11NOV 2016
	Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP		Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP

imported>Xenbase: /* correspondance from NIH */

2020-08-31T15:13:46Z

correspondance from NIH

← Older revision		Revision as of 15:13, 31 August 2020
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	ACTION BY XENBASE: 09/12/17		ACTION BY XENBASE: 09/12/17

	Changed;		Changed;
	~~selenop (XB-GENE-5866766) > selenop1 selenoprotein P1~~

	~~unnamed (~~XB-GENE-~~5872749) > selenop2l selenoprotein P2-like~~		XB-GENE-5866766 from ''selenop'' to ''selenop1, selenoprotein P1''

	~~updated names/symbols as requested~~, ~~added information to wiki~~		XB-GENE-5872749 from ''unnamed'' to ''selenop2l, selenoprotein P2-like''

	=summary from NCBI=		=summary from NCBI=
	This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (18 in Xenopus tropicalis), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017]		This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (18 in Xenopus tropicalis), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017]

imported>Xenbase: /* correspondance from NIH */

2020-08-31T15:01:51Z

correspondance from NIH

← Older revision		Revision as of 15:01, 31 August 2020
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	To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:22479358 table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter:		To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:22479358 table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter:

	~~current symbol name~~

	~~selenop (XB-GENE-5866766) > selenop1 selenoprotein P1~~

	unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like		current gene symbol gene name

			selenop (XB-GENE-5866766) > selenop1 selenoprotein P1

			unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like

imported>Xenbase at 18:02, 21 November 2017

2017-11-21T18:02:09Z

← Older revision		Revision as of 18:02, 21 November 2017
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	updated names/symbols as requested, added information to wiki		updated names/symbols as requested, added information to wiki

			=summary from NCBI=
			This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (18 in Xenopus tropicalis), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017]

imported>Xenbase: /* correspondance from NIH */

2017-09-19T12:51:56Z

correspondance from NIH

← Older revision		Revision as of 12:51, 19 September 2017
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	XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.		XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.

	selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues		selenop (GeneID:100379942, XB-GENE-5866766) encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals.
	(18), similar to SELENOP orthologs in mammals.

	'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like		'unnamed' (GeneID:448755,
			XB-GENE-5872749)has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like
	(PMIDs:22479358, 11168591), but it is NOT a selenoprotein.		(PMIDs:22479358, 11168591), but it is NOT a selenoprotein.

imported>Xenbase: /* correspondance from NIH */

2017-09-12T18:25:06Z

correspondance from NIH

← Older revision		Revision as of 18:25, 12 September 2017
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	Changed;		Changed;
	selenop (XB-GENE-5866766) > selenop1 selenoprotein P1		selenop (XB-GENE-5866766) > selenop1 selenoprotein P1

	unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like		unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like
	as requested
	added information to wiki		updated names/symbols as requested, added information to wiki

imported>Xenbase: /* nomenclature changes */

2017-09-12T18:23:51Z

nomenclature changes

← Older revision		Revision as of 18:23, 12 September 2017
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	11NOV 2016		11NOV 2016
	Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP		Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP

			12SEPT2017
			named changed (XB-GENE-5866766) from selenoprotein P, plasma, 1 to selenoprotein P1

			symbol changed (XB-GENE-5866766) from selenop to selenop1

			=correspondance from NIH=
			09/12/2017
			from Bhanu Rajput, Ph. D., Staff Scientist, Reference Sequence Project, NCBI/NLM/NIH.

			3. selenop (GeneID:100379942, XB-GENE-5866766) and 'unnamed' (GeneID:448755,
			XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.

			selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues
			(18), similar to SELENOP orthologs in mammals.

			'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like
			(PMIDs:22479358, 11168591), but it is NOT a selenoprotein.

			Some selenoprotein Pb proteins contain a single Sec residue (e.g., zebrafish NP_840083.2 and chicken NP_001335698.1), but in frog, Sec is replaced by cysteine.

			For this reason, naming this locus is hard because it represents a cysteine-containing
			homolog of selenoprotein Pb protein family.

			To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:22479358 table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter:

			current symbol name

			selenop (XB-GENE-5866766) > selenop1 selenoprotein P1

			unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like


			ACTION BY XENBASE: 09/12/17
			Changed;
			selenop (XB-GENE-5866766) > selenop1 selenoprotein P1
			unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like
			as requested
			added information to wiki

imported>Christina: /* selenop */

2016-11-29T15:40:06Z

selenop

← Older revision		Revision as of 15:40, 29 November 2016
Line 1:		Line 1:
	=~~sepp1~~=		=selenop=
	This is the community wiki page for the gene ''~~sepp1~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''selenop'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
			=nomenclature changes=
			11NOV 2016
			Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP