Xenbase: /* ccdc17 */

2026-02-12T15:10:04Z

ccdc17

← Older revision		Revision as of 15:10, 12 February 2026
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	=ccdc17=		=''ccdc17''=
	This is the community wiki page for the gene ''ccdc17'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''ccdc17'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

			=Annotation notes=

			12FEB2026

			John Wallingford reported an annotation issue regarding the '''''ccdc17.L''''' gene in the V.10 of the ''Xenopus laevis'' genome.

			In the previous (v9.2) genome model, ''ccdc17.L'' is annotated as a single gene encoding one transcript.

			https://www.xenbase.org/xenbase/displayJBrowse.do?data=data/xl9_2&loc=chr4L:79913279..79967099&tracks=XL9_2_Xenbase

			However, in the v10.1 genome model, the same locus, ''ccdc17.L'', appeared to be split into two separate genes (LOC121403046 and Ccdc17.L).

			https://www.xenbase.org/xenbase/displayJBrowse.do?data=data/xl10_1&loc=Chr4L:85244207..85263146&tracks=XL10_1_Xenbase

			''ccdc17'' in ''X. tropicalis'' is consistently annotated as a single transcript in the genome. And the new protein in v10 (loc121403046) appears to encode the protein that is the N-terminus portion of ''Ccdc17'' in ''X. tropicalis''.

			The structure of the ''ccdc17'' gene in ''X. laevis'' v9.2 and in the ''X. trop.'' genome is consistent with the structure of the Ccdc17 in other vertebrates.

			They also experimentally validated this gene structure using RT-PCR from a ''X. laevis'' cDNA library. The RT-PCR produced a single band of the expected size (~4.4 kb), consistent with the single-transcript model annotated in v9.2 (rather than the split annotation in v10.1).

			Based on this experimental evidence, they believed that the v9.2 ''ccdc17.L'' gene model represents the correct gene structure, and that the v10.1 annotation should be updated accordingly to reflect a single gene corresponding to the v9.2 model.

			JW communicated this to the NCBI refSeq team requesting a model correction.

			NCI replied as follows:

			''''[JW] you're correct regarding the annotation for ''Xenopus laevis ccdc17.L'' and thanks for bringing this to our attention.''''

			NCBI merged geneID 121403046 into 108714263 and created the following two coding RefSeqs;

			NM_001445330.1 transcript variant1 (1472aa)
			https://www.ncbi.nlm.nih.gov/nuccore/NM_001445330

			NM_001445333.1 transcript variant2 (693aa)
			https://www.ncbi.nlm.nih.gov/nuccore/NM_001445333

			These new RefSeqs should appear on [the NCBI] public facing pages within a few days.

imported>Xenbase: /* ccdc17 */Updated nomenclature, replaced: unnamed → ccdc17 (2)

2017-12-15T20:24:28Z

ccdc17: Updated nomenclature, replaced: unnamed → ccdc17 (2)

← Older revision		Revision as of 20:24, 15 December 2017
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	=~~unnamed~~=		=ccdc17=
	This is the community wiki page for the gene ''~~unnamed~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''ccdc17'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

imported>Xenbase gene generator at 12:00, 10 February 2010

2010-02-10T12:00:00Z

New page

=unnamed=
This is the community wiki page for the gene ''unnamed'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

XB-FEAT-948506 - Revision history

Xenbase: /* ccdc17 */

imported>Xenbase: /* ccdc17 */Updated nomenclature, replaced: unnamed → ccdc17 (2)

imported>Xenbase gene generator at 12:00, 10 February 2010