XB-FEAT-985294 - Revision history

Xenbase: /* nomenclature changes */

2026-08-27T18:42:07Z

nomenclature changes

← Older revision		Revision as of 18:42, 27 August 2026
Line 5:		Line 5:
	16MAY2026		16MAY2026

	''Xenopus'' gene name was updated to follow ~~taht~~ of ~~teh~~ human ortholog, changing from ''mtnr1c, melatonin receptor type 1C'' to ''gpr50'', ''G protein-coupled receptor 50''.		''Xenopus'' gene name was updated to follow that of the human ortholog, changing from ''mtnr1c, melatonin receptor type 1C'' to ''gpr50'', ''G protein-coupled receptor 50''.

	=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =		=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =

Xenbase: /* gpr50 */

2026-05-15T14:30:02Z

gpr50

← Older revision		Revision as of 14:30, 15 May 2026
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	=''gpr50''=		=''gpr50''=
	This is the community wiki page for the gene ''gpr50'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.		This is the community wiki page for the gene ''gpr50'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

			=nomenclature changes=
			16MAY2026

			''Xenopus'' gene name was updated to follow taht of teh human ortholog, changing from ''mtnr1c, melatonin receptor type 1C'' to ''gpr50'', ''G protein-coupled receptor 50''.

	=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =		=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =

Xenbase: /* mtnr1c */

2026-05-15T14:28:54Z

mtnr1c

← Older revision		Revision as of 14:28, 15 May 2026
Line 1:		Line 1:
	=''~~mtnr1c~~''=		=''gpr50''=
	This is the community wiki page for the gene ''~~mtnr1c~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase,		This is the community wiki page for the gene ''gpr50'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

	=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =		=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =

Xenbase: /* Notes on orthogy and phylogeny of Mtnr gene family */

2026-02-09T19:25:48Z

Notes on orthogy and phylogeny of Mtnr gene family

@@ Line 2: / Line 2: @@
 This is the community wiki page for the gene ''mtnr1c'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase,
-=Notes on orthogy and phylogeny of Mtnr gene family =
+=Notes on adaptive evolution, function, orthogy and phylogeny of Mtnr gene family =
 Source: Bertolesi et al 2020. The regulation of skin pigmentation in response to environmental light by
 pineal Type II opsins and skin melanophore melatonin receptors.  [https://www.sciencedirect.com/science/article/pii/S1011134420304747?via%3Dihub article online here.]
-"While life in different photic environments may have promoted the
+''While life in different photic environments may have promoted the diversification of opsins, the characteristics of pigmented skin cells and the genetic diversification of Mtnrs were likely influenced by the advent of thermoregulation. Pigment granules aggregate and disperse in skin melanophores of ectotherms, whereas in homeotherms, melanocytes release pigments that are then captured by neighboring keratinocytes [16]. The advent of skin isolation systems (fur and feathers in mammals and birds, respectively) during the evolution of thermoregulation [17], likely influenced both the phenotypic change (aggregation/dispersion vs. secretion) and the role of the Mtnrs in the skin. While three mtnrs are described in vertebrates (mtnr1a; mtnr1b and mtnr1c) [18], mtnr1c, initially identified in Xenopus skin melanophores [19], disappeared in therian mammalian lineages [20]. The Mtnr1c mammalian orthologue, GPR50, is expressed in hypothalamic thermoregulatory circuits, where it plays an important role in adaptative thermogenesis, despite having lost the ability to bind melatonin [21]. The presence of mtnr1a and mtnr1b in mammalian melanocytes [22], and mtnr1c in melanophores [19], argue that any or all Mtnrs could trigger pigment aggregation in non-mammalian vertebrates. The actual repertoire of Mtnrs involved,
-diversification of opsins, the characteristics of pigmented skin cells and
+however, is unknown.''

Xenbase: /* mtnr1c */

2026-02-09T19:22:34Z

mtnr1c

← Older revision		Revision as of 19:22, 9 February 2026
Line 1:		Line 1:
	=mtnr1c=		=''mtnr1c''=
	This is the community wiki page for the gene ''mtnr1c'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''mtnr1c'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase,

			=Notes on orthogy and phylogeny of Mtnr gene family =
			Source: Bertolesi et al 2020. The regulation of skin pigmentation in response to environmental light by
			pineal Type II opsins and skin melanophore melatonin receptors. [https://www.sciencedirect.com/science/article/pii/S1011134420304747?via%3Dihub article online here.]

			"While life in different photic environments may have promoted the
			diversification of opsins, the characteristics of pigmented skin cells and
			the genetic diversification of Mtnrs were likely influenced by the advent
			of thermoregulation. Pigment granules aggregate and disperse in skin
			melanophores of ectotherms, whereas in homeotherms, melanocytes
			release pigments that are then captured by neighboring keratinocytes
			[16]. The advent of skin isolation systems (fur and feathers in mammals
			and birds, respectively) during the evolution of thermoregulation [17],
			likely influenced both the phenotypic change (aggregation/dispersion
			vs. secretion) and the role of the Mtnrs in the skin. While three mtnrs are
			described in vertebrates (mtnr1a; mtnr1b and mtnr1c) [18], mtnr1c, initially
			identified in Xenopus skin melanophores [19], disappeared in
			therian mammalian lineages [20]. The Mtnr1c mammalian orthologue,
			GPR50, is expressed in hypothalamic thermoregulatory circuits, where
			it plays an important role in adaptative thermogenesis, despite having
			lost the ability to bind melatonin [21]. The presence of mtnr1a and
			mtnr1b in mammalian melanocytes [22], and mtnr1c in melanophores
			[19], argue that any or all Mtnrs could trigger pigment aggregation in
			non-mammalian vertebrates. The actual repertoire of Mtnrs involved,
			however, is unknown."

imported>Xenbase: /* mtnr1c */Updated nomenclature, replaced: unnamed → mtnr1c (2)

2017-12-15T22:57:21Z

mtnr1c: Updated nomenclature, replaced: unnamed → mtnr1c (2)

← Older revision		Revision as of 22:57, 15 December 2017
Line 1:		Line 1:
	=~~unnamed~~=		=mtnr1c=
	This is the community wiki page for the gene ''~~unnamed~~'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase		This is the community wiki page for the gene ''mtnr1c'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

imported>Xenbase gene generator at 12:00, 10 February 2010

2010-02-10T12:00:00Z

New page

=unnamed=
This is the community wiki page for the gene ''unnamed'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase