XB-FEAT-947876

mettl2a

This is the community wiki page for the gene mettl2a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

summary for human METTL2B from NCBI

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

nomenclature changes

06.16.2021

Human name has changed for Entrez Gene: 55798. From methyltransferase like 2B to methyltransferase 2B, methylcytidine

08JUNE 2023

Human name has changed for Entrez Gene: 55798. From methyltransferase 2B, methylcytidine to methyltransferase 2B, tRNA N3-cytidine

21MAY2026 Synteny suggests that Xenopus mettl2b has been misidentified and is not a true ortholog of human METTL2B, but instead is the orthologous to human METTL2A.

NCBI orthology predictions confirm this! 

THus the genes in Xtrop and Xlaevis on chr10 and 9_10L have been renamed mettle2a.