XB-FEAT-5907813

atp5mc2

This is the community wiki page for the gene atp5mc2. Please feel free to add any information relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

20MAY2026

Xenopus gene was renamed atp5mc2, changing from atp5mc1 following orthology analysis by NCBI. The genes were misidentified during genome annotation, and this new assignment is supported by synteny.

summary from NCBI for human ATP5MC2

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. This gene has multiple pseudogenes. [provided by RefSeq, Jan 2018]