XB-FEAT-5721916: Difference between revisions
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=tcirg1= | =tcirg1= | ||
This is the community wiki page for the gene ''tcirg1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''tcirg1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
04/22/ 2016 | |||
Human name has changed for Entrez Gene: 10312. From T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 to T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | |||
12/18/2017 | |||
Human name has changed for Entrez Gene: 10312. From T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 to T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | |||
=NCBI Summary= | |||
This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017] | |||
Latest revision as of 08:10, 3 January 2018
tcirg1
This is the community wiki page for the gene tcirg1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
04/22/ 2016
Human name has changed for Entrez Gene: 10312. From T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 to T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3
12/18/2017 Human name has changed for Entrez Gene: 10312. From T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 to T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
NCBI Summary
This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]