XB-FEAT-492277: Difference between revisions
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=nfatc2= | =nfatc2= | ||
This is the community wiki page for the gene ''nfatc2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''nfatc2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
04/22/ 2016 | |||
Human name has changed for Entrez Gene: 4773. From nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 to nuclear factor of activated T-cells 2 | |||
12/18/2017 | |||
Human name has changed for Entrez Gene: 4773. From nuclear factor of activated T-cells 2 to nuclear factor of activated T cells 2 | |||
=NCBI Summary= | |||
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] | |||
Latest revision as of 07:38, 3 January 2018
nfatc2
This is the community wiki page for the gene nfatc2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
04/22/ 2016
Human name has changed for Entrez Gene: 4773. From nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 to nuclear factor of activated T-cells 2
12/18/2017
Human name has changed for Entrez Gene: 4773. From nuclear factor of activated T-cells 2 to nuclear factor of activated T cells 2
NCBI Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]