XB-FEAT-976086: Difference between revisions
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=top3b= | =top3b= | ||
This is the community wiki page for the gene ''top3b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''top3b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
08/07/2017 | |||
Human name has changed for Entrez Gene: 8940. From topoisomerase (DNA) III beta to DNA topoisomerase III beta | |||
=summary from NCBI= | |||
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013] | |||
Latest revision as of 07:20, 8 August 2017
top3b
This is the community wiki page for the gene top3b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
08/07/2017
Human name has changed for Entrez Gene: 8940. From topoisomerase (DNA) III beta to DNA topoisomerase III beta
summary from NCBI
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]