BMS-453: Difference between revisions
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==Description== | ==Description== | ||
Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest. | Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest. | ||
[[File:bms 453.structure.png|frame|right|Bms 453 structure, | [[File:bms 453.structure.png|frame|right|Bms 453 structure, image from NCBI Pubchem]] | ||
==Alternative Name== | ==Alternative Name== | ||
BMS 189453 | BMS 189453 | ||
==Chemical Name== | ==Chemical Name== | ||
4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid | 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid | ||
==Suppliers== | ==Suppliers== | ||
[https://www.tocris.com/dispprod.php?ItemId=222005#.V2xIRfkrKM8 Tocris] | [https://www.tocris.com/dispprod.php?ItemId=222005#.V2xIRfkrKM8 Tocris] | ||
==References== | ==References== | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=51800| ''Using frogs faces to dissect the mechanisms underlying human orofacial defects''. Dickinson AJ. Semin Cell Dev Biol. March 1, 2016; 51 54-63.] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=51800| ''Using frogs faces to dissect the mechanisms underlying human orofacial defects''. Dickinson AJ. Semin Cell Dev Biol. March 1, 2016; 51 54-63.] | ||
*[http://www.xenbase.org/literature/article.do?articleId=44961&method=display| ''Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.'' Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.] | |||
*National Center for Biotechnology Information. PubChem Compound Database; CID=9875424, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9875424] | |||
Latest revision as of 13:34, 4 August 2016
Description
Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.
Alternative Name
BMS 189453
Chemical Name
4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
Suppliers
References
- Using frogs faces to dissect the mechanisms underlying human orofacial defects. Dickinson AJ. Semin Cell Dev Biol. March 1, 2016; 51 54-63.
- Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes. Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.
- National Center for Biotechnology Information. PubChem Compound Database; CID=9875424, [1]