PD173074: Difference between revisions
imported>Xenbase Created page with "PD173074, or PD 173074, is an FGFR1 and FGFR3 inhibitor. Chemical Name: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dime..." |
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Biologucal activity: Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. | Biologucal activity: Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. | ||
PubChem ID: 1401 | |||
Supplier: Tocris, Cat# 3044, https://www.tocris.com/products/pd-173074_3044 | |||
References: | |||
XB-ART-45962: PubMed ID: 22988910 | |||
Shifley ET , Kenny AP, Rankin SA , Zorn AM. 2012. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev Biol. December 17, 2012; 12 27. | |||
Latest revision as of 07:55, 25 August 2017
PD173074, or PD 173074, is an FGFR1 and FGFR3 inhibitor.
Chemical Name: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Biologucal activity: Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
PubChem ID: 1401
Supplier: Tocris, Cat# 3044, https://www.tocris.com/products/pd-173074_3044
References: XB-ART-45962: PubMed ID: 22988910 Shifley ET , Kenny AP, Rankin SA , Zorn AM. 2012. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev Biol. December 17, 2012; 12 27.