Barasertib: Difference between revisions
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==Description== | ==Description== | ||
Barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. | Barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. | ||
In XB-ART-54542, BAPTA-AM used to inhibit migration of the leading edge mesoderm in gastrulation. | |||
[[File:Barasertib.png|frame|right|Barasertib structure, image from PubChem]] | [[File:Barasertib.png|frame|right|Barasertib structure, image from PubChem]] | ||
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==Suppliers== | ==Suppliers== | ||
==Usage Notes== | ==Usage Notes== | ||
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*[http://www.xenbase.org/literature/article.do?method=display&articleId=53927 Hanley et al., 2017] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=53927 Hanley et al., 2017] | ||
> | > 8 Xenbase articles contain a reference to Barasertib or AZD1152 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | ||
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | ||
Latest revision as of 07:22, 15 February 2018
Description
Barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis.
In XB-ART-54542, BAPTA-AM used to inhibit migration of the leading edge mesoderm in gastrulation.
Alternative names
- AZD1152
- UNII-16XC2U7W8N
Suppliers
Usage Notes
References
> 8 Xenbase articles contain a reference to Barasertib or AZD1152 according to textpresso