XB-FEAT-984100: Difference between revisions
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=edaradd= | =''edaradd''= | ||
This is the community wiki page for the gene ''edaradd'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''edaradd'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=summary from NCBI for human EDARADD= | |||
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | |||
=nomenclature changes= | |||
31JAN2023 | |||
Human name has changed for Entrez Gene: 128178. From EDAR-associated death domain to EDAR associated via death domain | |||
Latest revision as of 14:29, 30 January 2023
edaradd
This is the community wiki page for the gene edaradd please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
summary from NCBI for human EDARADD
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
nomenclature changes
31JAN2023
Human name has changed for Entrez Gene: 128178. From EDAR-associated death domain to EDAR associated via death domain