XB-FEAT-6073788

hars1

This is the community wiki page for the gene hars1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

06.30.2020 Human symbol has changed for genepage ID: 6073788 From hars to HARS1

Note that amino acid and nucleotise trees suggest mammal HARS1 and HARS2 aren't strict orthologs of non-mammalian tandem HARS genes.

synteny notes: reptiles s.l. PCDH*<...ZMAT2<...HARS>...HARS>...DND1>...WDR55<...IK<

mammals PCDH*<...ZMAT2<...HARS2<...HARS1>...DND1>...WDR55<...IK<

amphibians (general pattern but lots of variation) PCDH*<...ZMAT2<...HARS>...HARS>...DND1>...UDGH<...WDR55<...IK<

Latimeria chalumnae ZMAT2<...HARS<...HARS<...LOC>...UDGH<...IK<

gar ZMAT2<...DND1>...HARS<...LOC>...UDGH<...WDR55<...IK<

reedfish PCDH*<...ZMAT2<...DND1>...HARS<...UDGH<...WDR55<...IK<

D.rerio //ZMAT2<// //DND1>...HARS<//

chondrichthyes PCDH*<...ZMAT2<...DND1>...HARS<...LOC>...UDGH<...IK<

HARS duplication possibly occured in sarcopterygii.

Ancestral gene may be multi-functional or Independent sub-functionalization following a duplication, or did sub-functionalization precede duplication and re-orientation?

summary for human HARS1 from NCBI

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]