XB-FEAT-480286

il12b

This is the community wiki page for the gene il12b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

summary for human IL12B from NCBI

IL12B - interleukin 12B

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

synteny of il12b and il12b-like across vertebrates

source: David Webb, NCBI RefSEQ team

Here's the synteny of IL12B: ( taxa, protein accession)

Human NP_002178.2, Koala XP_020848030.1, echidna XP_038627610.1:

EBF1< RNF145< UBLCP1> IL12B< LOCs>>> ADRA1B> TTC1> PWWP2A<

Gallus NP_998736.1, emu XP_025974440.1, crocodile XP_019390924:

FBXO38< spink-like< IL12B< LOCs> ADRA1B> TTC1> PWWP2A<

C.midas XP_007057329.3

FBXO38< spink-like< spink-like< IL12B< ADRA1B> TTC1> PWWP2A<

P. muralis XP_028576963.1

FBXO38< spink-like< spink-like> IL12B< KCNIP1< KCNMB1>

Xtr XP_031754537.1

EBF4< RNF145< UBLCP1> mmp21-like< IL12B< ADRA1B> havcr1-like< havcr1-like<

protopterus XP_043925850.1

ebf1< RNF145< UBLCP1> mmp21-like< IL12B< [unannotated region]

gar XP_006631788.2, sterlet XP_033907726.1

EBF1< RNF145< UBLCP1> mmp21-like< IL12B< EFCAB9> UBTD2<

skate XP_032885430.1 (note downstream synteny to IL12B-like)

ADAM19> UBLCP1> mmp21-like< IL12B< DOCK2> INSYN2B

D.rerio GeneID: 445373 (il12ba) ZDB-GENE-050525-3 & GeneID:335994 (il12bb) ZDB-GENE-030131-7937?

EBF1a< RNF145a< IL12Ba< ADRB2A> SH3TC2<

RARS< UBLCP1> IL12Bb< UBTD2< ADRB2b>

Here's the synteny of IL12B-like that is lost in mammals:

Gallus GeneID:101747944 XP_025006217.3

LBX2< PCGF1< TLX2> nefll> il12b-like< DQX1< dock2> insyn2b< bnip3L< AUP1< HTRA2>

Chelonia mydas

LBX2< PCGF1< TLX2> nefll> il12b-like< DQX1< dock2> insyn2b<

Podarcis muralis

LBX2< PCGF1< TLX2> nefll> il12b-like< DQX1< insyn2b< bnip3L< AUP1< HTRA2>

Xtr GeneID: 100493914 XP_031750962.1

TLX2> mmp21< il12b-like< DQX1< AUP1< HTRA2>

gar XP_015215443.1

TLX2> npm-like> fgf18L> PCGF1>// il12b-like< dqx1< avp<

skate XP_032900156.1

//il12b-like< DQX1< DOCK2L> insyn2b< bnip3L< AUP1<

mammals LBX2< PCGF1< TLX2> DQX1< AUP1< HTRA2> (missing!)