XB-FEAT-993074: Difference between revisions
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= | =''selenow''= | ||
This is the community wiki page for the gene '' | This is the community wiki page for the gene ''selenow'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | =nomenclature changes= | ||
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7.01.2020 | 7.01.2020 | ||
Note that this comes upin the Entrez gene report every month- do not change the name. The human ortholog to selenow1 is SELENOW, and there is no human ortholog to selenow2. | Note that this comes upin the Entrez gene report every month- do not change the name. The human ortholog to selenow1 is SELENOW, and there is no human ortholog to selenow2. | ||
05JUNE 2023 | |||
To comply with ''Xenopus'' nomenclature rules, we have changed the Xenopus symbol to ''selenow'' to match the human gene symbol, SELENOW, and have made ''selenow1''a synonym. for genepage ID: 993074 | |||
=NCBI summary= | =NCBI summary= | ||
Summary | Summary | ||
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017] | This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017] | ||
Latest revision as of 10:10, 6 June 2023
selenow
This is the community wiki page for the gene selenow please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
11/07/2016
Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW
Human symbol has changed for Entrez Gene: 6415. From SEPW1 to SELENOW
Human name has changed for Entrez Gene: 6415. From selenoprotein W, 1 to selenoprotein W
Mouse symbol has changed for Entrez Gene: 20364. From Sepw1 to Selenow
09/12/2017
correspondance from Bhanu Rajput, Ph. D. [Staff Scientist Reference Sequence Project NCBI/NLM/NIH] 2.) issue concerning selenow gene.
XB-GENE-993075 was previously associated with Entrez GeneID:100145402, which was withdrawn because it was based on a zebrafish transcript (BC160969.1) that was erroneously annotated as Xenopus tropicalis.
She moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene.
While reviewing this locus, she found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358).
This 2nd locus needed official nomenclature, and will be known by symbol selenow2 with gene name selenoprotein W2 (see below).
To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), she suggested the following nomenclature for the 2 paralogs:
current [[changes to > new symbol new name]]
selenow (XB-GENE-993075) changed to > selenow1 selenoprotein W1
new gene GeneID:101731107 changed to > selenow2 selenoprotein W2
ACTION BY XENBASE: 09/12/17
CHANGED name from SELENOW to SELENOW1 , as requested Submitted SELENOW2 data and requested a new gene page.
NEW GENE PAGE created : XB-GENEPAGE:22041594
7.01.2020 Note that this comes upin the Entrez gene report every month- do not change the name. The human ortholog to selenow1 is SELENOW, and there is no human ortholog to selenow2.
05JUNE 2023
To comply with Xenopus nomenclature rules, we have changed the Xenopus symbol to selenow to match the human gene symbol, SELENOW, and have made selenow1a synonym. for genepage ID: 993074
NCBI summary
Summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]