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| =nomenclature changes=
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| 18OCT23
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| ''Xenopus'' gene changed from ''MGC69520 , Novel 7 transmembrane receptor (rhodopsin family) protein'' to ''gpr4l.2, G protein-coupled receptor 4 like gene 2''.
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| This change was motivated to replace the MGC# symbol with something more meaningful, and was based on lack of synteny to true grp4 (see below) and a DIOPT/EggNog analysis, which aligned the protein to GPR4 in ~100 other species with very high confidence and similarity.
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| Although on the same chromosome as true ''gpr4'' gene, these 2 genes are not adjacent to true ''gpr4'', and therefore are not considered as gpr4 duplicates ( in which case they could be named ''gpr4.2'' and ''grp4.3''), but will be provisionally called 'like' genes.
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| XB5959819 symbol changed to ''grp4l.1/gpr4l''
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| MGC69520 symbol changed to ''grp4l.2''
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| =synteny=
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| 18OCT23
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| Note that true orthologs of GPR4 are flanked by ''elm1/2'' and ''opa3'' , while these '''grp4-like''' genes are flanked by ''shkbp1'' and ''sptbn4''.
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| Human: chr19: VASP> '''OPA3< GPR4< EML2<''' EML2-AS1>
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| ZFISH: CHR15: ''nova2> polr1g< '''gpr4< eml2<''' gipr>''
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| Xtrop.chr8: ''fbxo46< gipr< '''eml1> gpr4> opa3>'''''
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| Xtrop v10.chr8: ''shkbp1< '''XB5959819> MGC69520>''' sptbn4< ''
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| Annotation notes: XB5959819 and MGC69520 may end u/require merging as they seem to be partial/fragmented sequence accessions of the same gene. In this case, I still think the merged model should be ''grp4-like'' based on EggNog 5.0 analysis which matches both to the GRP4 protein tree.
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| [[File:Screenshot 2023-10-18 at 4.10.09 PM.png|thumb]]
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